Table 2 Ovarian Stimulation Characteristics and Cumulative live birth rates within POSEIDON and control groups

Patients (n)

4470

2270

1110

1095

8753

Oocyte retrieval cycles (n)

1.33 ± 0.64^a

1.54 ± 0.89^b

1.55 ± 0.94^b

1.97 ± 1.33^c

1.11 ± 0.38^d

<0.05

Retrieved oocytes (n)

5.97 ± 2.31^a

5.27 ± 2.34^b

7.07 ± 6.67^c

3.29 ± 3.05^d

16.84 ± 6.57^e

<0.05

Retrieved Oocytes / AFC (%)

58.02%

62.96%

199.21%

99.31%

109.28%

<0.05

Cycles of 0 oocyte Retrieved (%)

25 (0.4%)^a

12 (0.3%)^a

32 (1.9%)^b

51 (2.4%)^b

0 (0.0%)^c

<0.05

Insemination method

a

b

c

d

e

<0.05

 IVF

2878 (64.6%)

1486 (65.8%)

781 (70.9%)

752 (69.8%)

5069 (58.0%)

 ICSI

988 (22.2%)

572 (25.3%)

235 (21.3%)

290 (26.9%)

2047 (23.4%)

 IVF/ICSI

587 (13.2%)

201 (8.9%)

86 (7.8%)

36 (3.3%)

1630 (18.6%)

2PN embryos per oocyte retrieval cycle (n)

3.86 ± 2.08^a

3.44 ± 1.95^b

4.47 ± 4.26^c

2.16 ± 2.13^d

10.39 ± 5.09^e

<0.05

Good quality embryos per oocyte retrieval cycle (n)

2.15 ± 1.71^a

1.98 ± 1.55^b

2.38 ± 2.59^c

1.27 ± 1.39^d

5.32 ± 3.78^e

<0.05

FET cycles (n)

1.46 ± 0.81^a

1.58 ± 0.92^b

1.47 ± 0.78^a,b

1.54 ± 0.94^a,b

1.57 ± 0.88^b

<0.05

Transplanted embryos (n)

2.31 ± 1.61^a

2.50 ± 1.88^b

2.27 ± 1.70^a

2.01 ± 1.74^c

3.08 ± 1.88^d

<0.05

CLBR over 2 years

 Optimistic(95%CI)

0.76 (0.74–0.77)^a

0.55 (0.53–0.58)^b

0.67 (0.63–0.70)^c

0.36 (0.32–0.39)^d

0.76 (0.75–0.77)^e

<0.001

 Conservative(95%CI)

0.64 (0.62–0.65)^a

0.42 (0.40–0.44)^b

0.55 (0.52–0.58)^c

0.26 (0.23–0.29)^d

0.70 (0.70–0.71)^e

<0.001

CLBR over 5 years

 Optimistic(95%CI)

0.81 (0.79–0.82)^a

0.60 (0.57–0.63)^b

0.75 (0.71–0.78)^c

0.41 (0.37–0.46)^d

0.79 (0.78–0.80)^a

<0.001

 Conservative(95%CI)

0.66 (0.65–0.67)^a

0.44 (0.42–0.46)^b

0.58 (0.55–0.61)^c

0.27 (0.25–0.30)^d

0.72 (0.72–0.73)^e

<0.001