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Table 2 Ovarian Stimulation Characteristics and Cumulative live birth rates within POSEIDON and control groups

From: Cumulative live birth rates for low-prognosis women over 5 years or 9 frozen-thawed embryo transfer cycles

  POSEIDON group Control group P-value
Group1 Group2 Group3 Group4 Group5
Younger unexpected poor responders Older unexpected poor responders Younger expected poor responders Older expected poor responders
Patients (n) 4470 2270 1110 1095 8753  
Oocyte retrieval cycles (n) 1.33 ± 0.64a 1.54 ± 0.89b 1.55 ± 0.94b 1.97 ± 1.33c 1.11 ± 0.38d <0.05
Retrieved oocytes (n) 5.97 ± 2.31a 5.27 ± 2.34b 7.07 ± 6.67c 3.29 ± 3.05d 16.84 ± 6.57e <0.05
Retrieved Oocytes / AFC (%) 58.02% 62.96% 199.21% 99.31% 109.28% <0.05
Cycles of 0 oocyte Retrieved (%) 25 (0.4%)a 12 (0.3%)a 32 (1.9%)b 51 (2.4%)b 0 (0.0%)c <0.05
Insemination method a b c d e <0.05
 IVF 2878 (64.6%) 1486 (65.8%) 781 (70.9%) 752 (69.8%) 5069 (58.0%)  
 ICSI 988 (22.2%) 572 (25.3%) 235 (21.3%) 290 (26.9%) 2047 (23.4%)  
 IVF/ICSI 587 (13.2%) 201 (8.9%) 86 (7.8%) 36 (3.3%) 1630 (18.6%)  
2PN embryos per oocyte retrieval cycle (n) 3.86 ± 2.08a 3.44 ± 1.95b 4.47 ± 4.26c 2.16 ± 2.13d 10.39 ± 5.09e <0.05
Good quality embryos per oocyte retrieval cycle (n) 2.15 ± 1.71a 1.98 ± 1.55b 2.38 ± 2.59c 1.27 ± 1.39d 5.32 ± 3.78e <0.05
FET cycles (n) 1.46 ± 0.81a 1.58 ± 0.92b 1.47 ± 0.78a,b 1.54 ± 0.94a,b 1.57 ± 0.88b <0.05
Transplanted embryos (n) 2.31 ± 1.61a 2.50 ± 1.88b 2.27 ± 1.70a 2.01 ± 1.74c 3.08 ± 1.88d <0.05
CLBR over 2 years
 Optimistic(95%CI) 0.76 (0.74–0.77)a 0.55 (0.53–0.58)b 0.67 (0.63–0.70)c 0.36 (0.32–0.39)d 0.76 (0.75–0.77)e <0.001
 Conservative(95%CI) 0.64 (0.62–0.65)a 0.42 (0.40–0.44)b 0.55 (0.52–0.58)c 0.26 (0.23–0.29)d 0.70 (0.70–0.71)e <0.001
CLBR over 5 years
 Optimistic(95%CI) 0.81 (0.79–0.82)a 0.60 (0.57–0.63)b 0.75 (0.71–0.78)c 0.41 (0.37–0.46)d 0.79 (0.78–0.80)a <0.001
 Conservative(95%CI) 0.66 (0.65–0.67)a 0.44 (0.42–0.46)b 0.58 (0.55–0.61)c 0.27 (0.25–0.30)d 0.72 (0.72–0.73)e <0.001
  1. a,b,c,d,e P<0.05