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Table 1 Demographics and baseline characteristics of the participants in the first oocyte retrieval cycle

From: Cumulative live birth rates for low-prognosis women over 5 years or 9 frozen-thawed embryo transfer cycles

Group POSEIDON group Control group P value
Group1 Group2 Group3 Group4 Group5
Younger unexpected poor responders Older unexpected poor responders Younger expected poor responders Older expected poor responders
Patients (n) 4470 2270 1110 1095 8753  
Age of female 30.21 ± 2.76a 38.01 ± 2.83b 30.32 ± 2.71a,d 39.37 ± 3.38c 30.44 ± 3.85d <0.05
Percentage of age a b c d e <0.05
  ≤ 30 2234 (50.0%) 0 (0.0%) 541 (48.7%) 0 (0.0%) 4760 (54.4%)  
  > 30, ≤35 2236 (50.0%) 494 (21.8%) 569 (51.3%) 141 (12.9%) 3103 (35.5%)  
  > 35, ≤40 0 (0.0%) 1360 (59.9%) 0 (0.0%) 564 (51.5%) 796 (9.1%)  
  > 40 0 (0.0%) 416 (18.3%) 0 (0.0%) 390 (35.6%) 94 (1.1%)  
AFC 11.17 ± 5.77a 8.99 ± 4.09b 2.19 ± 1.65c 2.51 ± 1.32c 15.24 ± 6.21d <0.05
Percentage of AFC a b c c d <0.05
  < 4 0 (0.0%) 0 (0.0%) 750 (67.6%) 776 (70.9%) 0 (0.0%)  
  ≥ 4, < 10 2185 (48.9%) 1502 (66.2%) 360 (32.4%) 319 (29.1%) 1444 (16.5%)  
  ≥ 10 2285 (51.1%) 768 (33.8%) 0 (0.0%) 0 (0.0%) 7309 (83.5%)  
Oocytes retrieved in the first cycle (n) 5.97 ± 2.31a 5.27 ± 2.34b 7.07 ± 6.67c 3.29 ± 3.05d 16.84 ± 6.57e <0.05
Type of infertility a b c d e <0.05
 Primary 2673 (59.8%) 848 (37.4%) 713 (64.2%) 383 (35.0%) 5059 (57.8%)  
 Secondary 1797 (40.2%) 1422 (62.6%) 397 (35.8%) 712 (65.0%) 3694 (42.2%)  
Main etiology a b c d e <0.05
 Female 460 (10.3%) 240 (10.6%) 94 (8.5%) 69 (6.3%) 1076 (12.3%)  
 Male 2945 (65.9%) 1401 (61.7%) 770 (69.4%) 741 (67.7%) 5567 (63.6%)  
 Combined 539 (12.0%) 236 (10.4%) 126 (11.3%) 132 (12.0%) 1059 (12.1%)  
 Others 526 (11.8%) 393 (17.3%) 120 (10.8%) 153 (14.0%) 1051 (12.0%)  
Duration of infertility (years) 2.93 ± 2.42a 4.08 ± 3.96b 3.14 ± 2.46c 4.32 ± 4.56d 3.01 ± 2.70a,c <0.05
Female BMI (kg/m2) 22.00 ± 4.74a 22.26 ± 3.07b 21.78 ± 5.87a,c 22.16 ± 2.88a,b 21.64 ± 3.31c <0.05
Year of treatment a b c d e <0.05
 2013–2014 1160 (26.0%) 526 (23.2%) 309 (27.8%) 304 (27.8%) 2248 (25.7%)  
 2015 859 (19.2%) 375 (16.5%) 258 (23.2%) 180 (16.4%) 1821 (20.8%)  
 2016 1349 (30.2%) 730 (32.2%) 362 (32.6%) 348 (31.8%) 2188 (25.0%)  
 2017 683 (15.3%) 353 (15.6%) 111 (10.0%) 172 (15.7%) 1353 (15.5%)  
 2018 419 (9.4%) 286 (12.6%) 70 (6.3%) 91 (8.3%) 1143 (13.1%)  
Gravidity 0.71 ± 1.27a 1.42 ± 1.53b 0.62 ± 1.04c 1.48 ± 1.52b 0.74 ± 1.09a <0.05
Parity 0.06 ± 0.26a 0.27 ± 0.48b 0.05 ± 0.23a 0.30 ± 0.51b 0.08 ± 0.30c <0.05
  1. Values are presented as mean ± SD or number (percentage). The differences were considered statistically significant when the p-value was less than 0.05. Different alphabets represent significant differences between groups. AFC Antral follicle count, BMI Body mass index
  2. a,b,c,d,e P<0.05