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Table 3 Clinical pregnancy outcomes stratified by MTHFR C677T genotype.

From: MTHFR 677TT is associated with decreased number of embryos and cumulative live birth rate in patients undergoing GnRHa short protocol: a retrospective study

 

Total N=1173

Long protocol N=730

Short protocol N=443

CC N=500

CT N=546

TT N=127

P-value

CC N=297

CT N=348

TT N=85

P-value

CC N=203

CT N=198

TT N=42

P-value

hCG positive rate

301 (60.20%)

325 (59.52%)

73 (57.48%)

0.855

200 (67.34%)

222 (63.79%)

55 (64.71%)

0.635

101 (49.75%)

103 (52.02%)

18 (42.86%)

0.553

CPR

256 (51.20%)

280 (51.28%)

63 (49.61%)

0.941

177 (59.60%)

200 (57.47%)

49 (57.65%)

0.853

79 (38.92%)

80 (40.40%)

14 (33.33%)

0.694

Miscarriage rate

31 (6.20%)

27 (4.95%)

8 (6.30%)

0.639

18 (6.06%)

19 (5.46%)

6 (7.06%)

0.843

13 (6.40%)

8 (4.04%)

2 (4.76%)

0.561

LBR

225 (45.00%)

245 (44.87%)

52 (40.94%)

0.694

155 (52.19%)

178 (51.15%)

40 (47.06%)

0.706

70 (34.48%)

67 (33.84%)

12 (28.57%)

0.759

CLBR

287 (57.40%)

287 (52.56%)

67 (52.76%)

0.263

185 (62.29%)

208 (59.77%)

54 (63.53%)

0.725

102 (50.25%)a*

79 (39.90%)b NS

13 (30.95%)c*

0.024

  1. Note: The categorical variables were presented as percentages (frequencies) and analyzed by chi-square test. P < 0.05 was considered as statistically significant. MTHFR 5,10-Methylenetetrahydrofolate reductase, hCG Human chorionic gonadotrophin, CPR Clinical pregnancy rate, LBR Live birth rate, CLBR Cumulative live birth rate. a: CC versus CT (p-value=0.048). b: CT versus TT (p-value=0.364). c: TT versus CC (p-value=0.035). * P < 0.05, NS: not significant.