Skip to main content

Table 1 Baseline characteristics stratified by MTHFR C677T genotype

From: MTHFR 677TT is associated with decreased number of embryos and cumulative live birth rate in patients undergoing GnRHa short protocol: a retrospective study

 

Total N=1173

Long protocol N=730

Short protocol N=443

 

CC N=500

CT N=546

TT N=127

P-value

CC N=297

CT N=348

TT N=85

P-value

CC N=203

CT N=198

TT N=42

P-value

Age (Year)

30.52 (4.90)

30.65 (4.89)

30.66(4.69)

0.892

29.57 (4.09)

29.80 (4.23)

30.02 (4.69)

0.623

31.91 (5.62)

32.15 (5.58)

31.95 (4.48)

0.906

BMI (kg/m2)

21.47 (1.82)

21.39 (1.90)

21.50 (1.86)

0.732

21.43 (1.89)

21.30 (1.89)

21.34 (1.90)

0.666

21.52 (1.72)

21.55 (1.92)

21.82 (1.73)

0.622

Infertility Type:

   

0.695

   

0.936

   

0.497

Primary infertility

231 (46.20%)

239 (43.77%)

59 (46.46%)

 

144 (48.48%)

164 (47.13%)

40 (47.06%)

 

87 (42.86%)

75 (37.88%)

19 (45.24%)

 

Secondary infertility

269 (53.80%)

307 (56.23%)

68 (53.54%)

 

153 (51.52%)

184 (52.87%)

45 (52.94%)

 

116 (57.14%)

123 (62.12%)

23 (54.76%)

 

Infertility Year

4.28 (3.49)

4.18 (3.15)

4.31 (3.36)

0.842

3.92 (3.10)

4.19 (3.10)

3.98 (2.49)

0.513

4.81 (3.95)

4.15 (3.25)

5.00 (4.62)

0.145

Infertility cause:

   

0.021

   

0.035

   

0.282

Male factor

61 (12.20%)

39 (7.14%)

13 (10.24%)

 

38 (12.79%)

24 (6.90%)

7 (8.24%)

 

23 (11.33%)

15 (7.58%)

6 (14.29%)

 

Female factor

439 (87.80%)

507 (92.86%)

114 (89.76%)

 

259 (87.21%)

324 (93.10%)

78 (91.76%)

 

180 (88.67%)

183 (92.42%)

36 (85.71%)

 

Protocol:

   

0.181

        

Long protocol

297 (59.40%)

348 (63.74%)

85 (66.93%)

         

Short protocol

203 (40.60%)

198 (36.36%)

42 (33.07%)

         

Endometrial Thickness

10.53 (2.20)

10.67 (2.11)

10.64 (2.25)

0.596

10.92 (2.16)

11.07 (2.21)

10.96 (2.37)

0.675

9.97 (2.14)

9.96 (1.71)

10.00 (1.86)

0.994

Endometrial Pattern:

   

0.494

   

0.912

   

0.257

A

224 (44.80%)

239 (43.77%)

64 (50.39%)

 

144 (48.48%)

165 (47.41%)

42 (49.41%)

 

80 (39.41%)

74 (37.37%)

22 (52.38%)

 

B

256 (51.20%)

277 (50.73%)

59 (46.46%)

 

143 (48.15%)

166 (47.70%)

39 (45.88%)

 

113 (55.67%)

111 (56.06%)

20 (47.62%)

 

C

20 (4.00%)

30 (5.49%)

4 (3.15%)

 

10 (3.37%)

17 (4.89%)

4 (4.71%)

 

10 (4.93%)

13 (6.57%)

0 (0.00%)

 

basalFSH

6.59 (1.56)

6.62 (1.70)

6.54 (1.50)

0.841

6.46 (1.47)

6.57 (1.75)

6.17 (1.30)

0.115

6.77 (1.67)

6.73 (1.60)

7.29 (1.62)

0.122

basalLH

5.85 (3.14)

5.52 (3.19)

5.59 (3.04)

0.229

5.93 (2.95)

5.63 (3.37)

5.60 (2.91)

0.446

5.73 (3.41)

5.32 (2.85)

5.57 (3.32)

0.421

Gn start dose

164 (50.44)

165 (51.22)

162 (52.19)

0.736

157 (47.24)

160 (48.05)

155 (49.87)

0.516

175 (53.17)

174 (55.37)

175 (54.73)

0.995

Gn Day

10.5 (2.47)

10.5 (2.38)

10.4 (2.18)

0.947

11.13 (2.37)

11.06 (2.13)

10.99 (2.01)

0.842

9.57 (2.33)

9.41 (2.42)

9.29 (2.09)

0.701

Gn total dose

1917 (662)

1925 (662)

1845 (626)

0.455

1980 (639)

2009 (668)

1894 (647)

0.345

1826 (685)

1779 (627)

1746 (574)

0.669

Fertilization method

   

0.149

   

0.024

   

0.655

IVF

342(68.40%)

403(73.81%)

88(69.29%)

 

200(67.34%)

258(74.14%)

60(70.59%)

 

142(69.95%)

145(73.23%)

28(66.67%)

 

ICSI

153(30.60%)

132(24.18%)

37(29.13%)

 

96(32.32%)

81(23.28)

23(27.06)

 

57(28.08%)

51(25.76%)

14(33.33%)

 

IVF+ICSI

5(1.00%)

11(2.01%)

2(1.57%)

 

1(0.34%)

9(2.59%)

2(2.35%)

 

4(1.97%)

2(1.01%)

0(0.00%)

 

No of ET

   

0.798

   

0.293

   

0.276

1

44 (8.80%)

44 (8.06%)

9 (7.09%)

 

17 (5.72%)

27 (7.76%)

3 (3.53%)

 

27 (13.30%)

17 (8.59%)

6 (14.29%)

 

2

456 (91.20%)

502 (91.94%)

118 (92.91%)

 

280 (94.28%)

321 (92.24%)

82 (96.47%)

 

176 (86.70%)

181 (91.41%)

36 (85.71%)

 
  1. Note: The continuous variables were presented as mean (SD) and analyzed by ANOVA analysis, the categorical variables were presented as percentages (frequencies) and analyzed by chi-square test. P < 0.05 was considered as statistically significant. MTHFR 5,10-Methylenetetrahydrofolate reductase, BMI Body mass index, SD Standard deviation, FSH Follicle stimulating hormone, LH Luteinizing hormone, IVF In-vitro fertilization, ICSI Intracytoplasmic sperm injection, Gn Gonadotrophin, No Number
Back to article page

BMC Pregnancy and Childbirth

ISSN: 1471-2393

Contact us