Fig. 1

Heatmap showing the metabolome profiles of plasma and urine in the first and third trimester. The relative abundance of metabolites is illustrated on a log2 scale. Fold difference of metabolite concentrations compared with their corresponding controls are plotted as shades of purple (increasing levels) or yellow (decreasing levels). Only metabolites with a significant p-value (Tukey’s HSD: p < 0.05), q-value (FDR: q < 0.1) are shown