Table 2 Comparison of data for Double/Triple, cFTS/Quadruple and NIPT screening tests
Grouped period screening policy | A. 2006-2010 Double/Triple | B. 2011-2015 cFTS/quadruple | C. 2016-2019 NIPT | Chi-Square Test p value | Pairwise Comparison (Proportional test with Bonferroni correction) |
|---|---|---|---|---|---|
Registered live births | 964523 | 1052378 | 758891 | ||
Maternal age≧ 35 (%) | 131941 (13.7) | 232418 (22.1) | 221283 (29.2) | <0.001 | C > B > A |
Total No. invasive prenatal diagnosis | 172673 | 260443 | 185730 | ||
Maternal age≧ 35 (%) | 124492 (72.1) | 213930 (82.1) | 160441 (86.4) | <0.001 | C > B > A |
Invasive diagnosis rate | |||||
All age | 17.90% | 24.75% | 24.47% | <0.001 | B > C > A |
Maternal age≧ 35 | 94.35% | 92.05% | 72.50% | <0.001 | A > B > C |
Total Trisomy 21 | 1051 | 1680 | 1366 | ||
Trisomy 21 livebirths (%) | 223 (21.2) | 135 (8.0) | 51 (3.7) | <0.001 | A > B > C |
Total Trisomy 18 | 204 | 487 | 388 | ||
Trisomy 18 livebirths (%) | 19 (9.3) | 11 (2.3) | 6 (1.5) | <0.001 | A > (B , C) |
Total trisomy 13 | 62 | 139 | 116 | ||
Trisomy 13 livebirths (%) | 8 (12.9) | 4 (2.9) | 0 | <0.001 | A > (B , C) |