Table 2 Univariable and multivariable logistic regression analyses were used to confirm several possible factors affecting co-twin fetal loss after RFA
Variable | Group 1 co-twin alive N = 241 | Group 2 co-twin loss N = 65 | Univariate | Multivariate | ||
|---|---|---|---|---|---|---|
(n,%) | (n,%) | P | OR (95% CI) | P | OR (95% CI) | |
Gestational weeks at RFA | ||||||
≤20 weeks | 106 (43.9) | 28 (43.1) | 0.9 | 0.96(0.55–1.68) | 0.68 | 1.14 (0.61–2.21) |
>20 weeks | 135 (56) | 37 (56.9) |  | reference |  | reference |
Chorionicity | ||||||
Monochorionic | 215 (89.2) | 61 (93.8) | 0.77 | 1.14 (0.47–2.80) | 0.91 | 0.95 (0.37–2.41) |
Dichorionic | 26 (10.8) | 4 (6.2) | Â | reference | Â | reference |
Indications of RFA | ||||||
TTTS | 60 (24.9) | 31 (47.7) | Â | reference | Â | reference |
sFGR | 75 (31.1) | 8 (12.3) | < 0.001 | 2.06 (0.09–0.482) | < 0.001 | 0.21 (0.09–0.5) |
Discordant Anomalies | 61 (25.3) | 17 (26.2) | 0.08 | 0.54 (0.27–1.08) | 0.07 | 0.53 (0.26–1.06) |
MFPR | 28 (11.6) | 4 (6.2) | 0.03 | 0.28 (0.09–0.86) | 0.03 | 0.27 (0.08–0.87) |
TRAPS | 14 (5.8) | 5 (7.7) | 0.51 | 0.69 (0.23–2.10) | 0.43 | 0.63 (0.2–1.98) |
TAPS | 3 (1.2) | 0 (0) | 1 | N/A | 1 | N/A |
Cycles of RFA coagulation | ||||||
≤2 | 193 (80.1) | 48 (73.8) | 0.28 | 0.70 (0.37–1.33) | 0.3 | 0.7(0.35–1.37) |
>2 | 48 (19.9) | 17 (26.2) | Â | reference | Â | reference |
Duration of RFA (min) | ||||||
≤15 | 169(70.1) | 49(75.4) | 0.41 | 0.77 (0.41–1.44) | 0.49 | 1.26(0.65–2.45) |
>15 | 72(29.5) | 16(24.6) | Â | reference | Â | reference |