Table 2 Definitions of PRD

 Pregnancy induced hypertension

Two independent measurements (time gap at least 4 hours) after 20 weeks GA of a systolic blood pressure ≥140mmHg AND/OR a diastolic blood pressure ≥90mmHg (severe hypertension = systolic blood pressure ≥160mmHg, AND/OR diastolic blood pressure ≥110mmHg).

 Pre-eclampsia

- Hypertension as described above AND one or more of the following:

- Proteinuria AND/OR:

 ○ Protein/creatinine ratio ≥30mg/mmol OR;

 ○ Proteinuria of ≥300mg/24 hour.

(Massive proteinuria = protein/creatinine ratio >500mg/mmol OR >5g/24 hour)

- Uteroplacental dysfunction (such as FGR, abnormal umbilical artery Doppler, or stillbirth) AND/OR:

- Other maternal organ dysfunction, including:

 ○ Acute kidney injury (creatinine ≥ 90μmol/L).

 ○ Liver involvement (elevated transaminases e.g. ALAT or ASAT > 40U/L).

 ○ Neurological complications (eclampsia, altered mental state, blindness, stroke, clonus, severe headaches, persistent visual scotoma).

 ○ Haematological complications (thrombocytopenia <150,000/μL, DIC, haemolysis).

 HELLP-syndrome

Combination of symptoms that signifies a more serious manifestation of pre-eclampsia [1]. Defined as a combination of:

- Haemolysis (LDH ≥600 U/L, haptoglobin <0.2g/L AND;

- Elevated liver enzymes (ASAT or ALAT >70U/L) AND;

- Low platelets (<100*10⁹/L).

FGR [22]

Birthweight corrected for GA <10th percentile.

Preterm birth [23]

Babies born alive <37 weeks GA.

- Extremely preterm: <28 weeks GA.

- Very preterm: 28 to 32 weeks GA.

- Moderate to late preterm: 32 to 37 weeks GA.