Association of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study

Table 4 Associations between parental prepregnancy BMI and any birth defect in multilevel logistic regression analyses

Any birth defect	Reference group				OR (95% CI) ^a	P value ^b	aOR (95% CI) ^c	P value ^b
Singletons
IVF	A(M&P<25)	35(5.8)	B(M < 25&P ≥ 25)	26(9.8)	1.76(1.04,2.99)	0.036	1.82(1.06,3.10)	0.029
			C(M ≥ 25&P < 25)	5(7.1)	1.25(0.47,3.30)	0.652	1.23(0.46,3.28)	0.677
			D(M&P ≥ 25)	3(6.3)	1.08(0.32,3.66)	0.897	1.18(0.34,4.04)	0.797
ICSI	A(M&P<25)	8(3.7)	B(M < 25&P ≥ 25)	8(7.2)	2.02(0.74,5.53)	0.172	2.10(0.76,5.84)	0.155
			C(M ≥ 25&P < 25)	5(14.7)	4.48(1.37,14.63)	0.013	4.89(1.45,16.53)	0.011
			D(M&P ≥ 25)	1(5.9)	1.63(0.19,13.81)	0.657	1.57(0.18,13.60)	0.685
Twins
IVF	A(M&P<25)	25(5.9)	B(M < 25&P ≥ 25)	22(9.6)	1.69(0.93,3.07)	0.086	1.69(0.92,3.09)	0.089
			C(M ≥ 25&P < 25)	5(8.3)	1.45(0.53,3.95)	0.466	1.73(0.62,4.81)	0.293
			D(M&P ≥ 25)	0	–	–	–	–
ICSI	A(M&P<25)	9(7.1)	B(M < 25&P ≥ 25)	1(1.5)	0.20(0.03,1.61)	0.131	0.21(0.03,1.73)	0.146
			C(M ≥ 25&P < 25)	1(10.0)	1.44(0.16,12.71)	0.740	2.06(0.21,20.51)	0.539
			D(M&P ≥ 25)	1(12.5)	1.86(0.21,16.80)	0.582	0.89(0.09,9.20)	0.925

Values are presented as frequency (percentage)
^a Odds ratio (OR) and 95% confidence interval (CI) were calculated from logistic regression models to reflect the association between parental prepregnancy BMI and any birth defect
^b P value is based on logistic regression analyses. Results in bold indicate statistical significance (P < 0.05)
^c aOR: Adjusted models are controlled for parental age, type of infertility, duration of infertility, ovulatory dysfunction and endometriosis
BMI body mass index, IVF in vitro fertilization, P paternal prepregnancy BMI, REF reference group

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