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Table 2 The neonatal outcomes compared by maternal and paternal prepregnancy BMI

From: Association of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study

Variable

IVF

ICSI

A(M&P < 25)

B(M < 25&P ≥ 25)

C(M ≥ 25&P < 25)

D(M&P ≥ 25)

P value a

A(M&P < 25)

B(M < 25&P ≥ 25)

C(M ≥ 25&P < 25)

D(M&P ≥ 25)

P value a

Singletons

 No. of cycles/newborns

668

298

93

60

 

234

117

42

22

 

 Cesarean section

401(60.0)

179(60.1)

71(76.3)

40(66.7)

0.017

128(54.7)

73(62.4)

31(73.8)

13(59.1)

0.104

 Gestational age(wk)

38.61 ± 1.54

38.66 ± 1.58

38.22 ± 2.09

38.68 ± 1.43

0.114

38.62 ± 1.67

38.84 ± 1.38

38.19 ± 2.30

38.50 ± 1.68

0.184

 Premature birth

45(6.7)

18(6.0)

10(10 .8)

6(10.0)

0.306

15(6.4)

7(6.0)

5(11.9)

3(13.6)

0.279

Gender

0.008

 

0.268

 Boys

375(56.1)

162(54.4)

36(38.7)

27(45.0)

 

120(51.3)

61(52.1)

24(57.1)

7(31.8)

 

 Girls

293(43.9)

136(45.6)

57(61.3)

33(55.0)

 

114(48.7)

56(47.9)

18(42.9)

15(68.2)

 

 Birth weight(kg)

3.24 ± 0.47

3.31 ± 0.48

3.29 ± 0.60

3.35 ± 0.55

0.098

3.29 ± 0.52

3.34 ± 0.46

3.35 ± 0.70

3.38 ± 0.46

0.699

 Birth weight (kg, boys)

3.29 ± 0.49

3.36 ± 0.48

3.27 ± 0.68

3.35 ± 0.66

0.551

3.38 ± 0.46

3.33 ± 0.53

3.36 ± 0.60

3.18 ± 0.30

0.693

 Birth weight (kg, girls)

3.17 ± 0.42

3.25 ± 0.48

3.30 ± 0.56

3.35 ± 0.45

0.031

3.19 ± 0.56

3.35 ± 0.38

3.34 ± 0.83

3.48 ± 0.49

0.086

 Low birth weight infant

35(5.2)

15(5.0)

11(11.8)

2(3.3)

0.086

10(4.3)

5(4.3)

3(7.1)

0

0.713

 Fetal macrosomia

34(5.1)

16(5.4)

7(7.5)

9(15.0)

0.030

18(7.7)

9(7.7)

8(19.0)

3(13.6)

0.093

 SGA

52(7.8)

18(6.0)

6(6.5)

3(5.0)

0.787

16(6.8)

7(6.0)

2(4.8)

2(9.1)

0.909

 LGA

68(10.2)

48(16.1)

20(21.5)

12(20.0)

0.001

29(12.4)

14(12.0)

11(26.2)

7(31.8)

0.010

Twins

 No. of cycles

226

120

37

24

 

73

34

5

4

 

 Cesarean section

213(94.2)

116(96.7)

35(94.6)

24(100.0)

0.668

71(97.3)

33(97.1)

5(100.0)

4(100.0)

1.000

 Gestational age(wk)

36.11 ± 1.93

35.86 ± 2.10

35.65 ± 2.23

35.58 ± 2.57

0.375

36.37 ± 1.59

36.29 ± 1.77

36.2 ± 1.92

36.50 ± 1.73

0.989

 Premature birth

115(50.9)

62(51.7)

21(56.8)

14(58.3)

0.840

34(46.6)

15(44.1)

2(40.0)

1(25.0)

0.906

 No. of newborns

452

240

74

48

 

146

68

10

8

 

Gender

0.985

 

0.829

 Boys

230(50.9)

125(52.1)

37(50.0)

25(52.1)

 

73(50.0)

33(48.5)

4(40.0)

5(62.5)

 

 Girls

222(49.1)

115(47.9)

37(50.0)

23(47.9)

 

73(50.0)

35(51.5)

6(60.0)

3(37.5)

 

 Birth weight(kg)

2.44 ± 0.46

2.38 ± 0.47

2.41 ± 0.59

2.39 ± 0.59

0.366

2.49 ± 0.49

2.46 ± 0.40

2.40 ± 0.42

2.74 ± 0.38

0.382

 Birth weight (kg, boys)

2.48 ± 0.49

2.44 ± 0.46

2.63 ± 0.62

2.42 ± 0.58

0.247

2.52 ± 0.48

2.48 ± 0.51

2.69 ± 0.29

2.71 ± 0.48

0.697

 Birth weight (kg, girls)

2.41 ± 0.43

2.31 ± 0.48

2.20 ± 0.49

2.36 ± 0.60

0.031

2.47 ± 0.50

2.44 ± 0.27

2.20 ± 0.40

2.80 ± 0.22

0.270

 Low birth weight infant

218(48.2)

134(55.8)

38(51.4)

17(35.4)

0.047

67(45.9)

33(48.5)

6(60.0)

1(12.5)

0.203

 Fetal macrosomia

0

0

1(1.4)

0

0.150

1(0.7)

0

0

0

1.000

 SGA

153(33.8)

86(35.8)

27(36.5)

10(20.8)

0.233

51(34.9)

28(41.2)

5(50.0)

1(12.5)

0.315

 LGA

2(0.4)

0

1(1.4)

0

0.322

1(0.7)

0

1(10.0)

0

0.149

  1. Values are presented as mean ± SD or frequency (percentage)
  2. a P value is based on One-Way ANOVA for continuous variables and χ2 test for categorical variables across maternal and paternal prepregnancy BMI. Results in bold indicate statistical significance (P < 0.05)
  3. BMI body mass index, M maternal prepregnancy BMI, P paternal prepregnancy BMI, IVF in vitro fertilization, ICSI intracytoplasmic sperm injection, wk week, SGA small for gestational age, LGA large for gestational age