Study and year | Study design | Country and time period | Setting | Total number | Demographics | Past Medical History | |
---|---|---|---|---|---|---|---|
Symptomatic | asymptomatic | Symptomatic | |||||
Dongmei Cao 2020 [23] | Case-series | Wuhan, China Jan 23rd to Feb 23rd 2020 | Maternal and Child health hospital | Total = 10 Symp = 7 Asymp = 3 | Mean age:30.6 Mean Gest. Age: 37 + 6 | Mean Age: 29.7 Mean Gest. Age: 37 + 5 | Hypothyroid = 1 Anemia = 1 |
Ensiyeh Jenabi, 2020 [26] | Case-control | Hamadan Province, Iran Sept 1 to Nov 15, 2020 | Hospitals of Hamadan Province located in West Iran | Total = 90 Symp = 45 Asymp = 45 | Mean age = 29.47 Mean Gestational age = 37.13 | Mean age = 28.78 Mean Gestational age = 37.62 | Comorbidity disease = 3 |
Gabrielle Saccone 2020 [17] | Retrospective cohort | 22 different countries (Argentina, Australia, Belgium, Brazil, Colombia, Czech Republic, Finland, Germany, Greece, Israel, Italy, North Macedonia, Peru, Portugal, Republic of Kosovo, Romania, Russia, Serbia, Slovenia, Spain, Turkey, and United States) February 1, 2020 and April 30, 2020 | Various hospitals | Total = 388 Symp = 294 Asymp = 94 | N/A | N/A | N/A |
Jayasree Santhosh2020 [18] | Cohort study | Muscat, Oman March 24 to July 31, 2020 | The Royal Hospital | Total = 60 Symp = 44 Asymp = 16 | N/A | N/A | Hypertension = 1 Diabetes = 2 GDM = 12 Hematologic disease = 7 |
Nicola Vousden2021 [19] | Prospective Cohort | United Kingdom March 1 to August 31, 2020 | 194 hospitals vis UK Obstetric Surveillance System (UKOSS) | Total = 1148 Symp = 722 Asymp = 426 | Race-ethnicity: White = 318 Asian = 210 Black = 122 Chinese = 8 Other = 36 Mixed = 15 Current smoking = 42 | Race-ethnicity: White = 276 Asian = 84 Black = 33 Chinese = 4 Other = 16 Mixed = 5 Current smoking = 57 | Asthma = 49 Hypertension = 24 Cardiac disease = 13 Diabetes = 22 |
Sourabh Verma, 2020 [20] | Cohort study | New York, USA March 1 to May 10, 2020 | New York University (NYU) Langone Health system hospitals (NYU Tisch, NYU Brooklyn, NYU Winthrop) and Bellevue Hospital Center | Total = 149 Symp = 89 Asymp = 60 | Mean age = 32 BMI (> = 30) = 38 | Mean age = 30.4 BMI (> = 30) = 24 | Asthma = 6 Diabetes = 2 Gestational Diabetes = 5 Gestational hypertension = 12 |
Torri Metz 2021 [21] | Cohort study | 14 states USA March 1st to July 31st, 2020 | 33 National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) sites | Total = 1219 Symp = 640 Asymp = 579 | Mean Age = 30 BMI (> = 30) = 328 Race-ethnicity: Black = 152 White = 101 Hispanic = 327 Smoked = 23 | Mean Age = 28 BMI (> = 30) = 561 Race-ethnicity: Black = 123 White = 80 Hispanic = 324 Smoked = 27 | Asthma or COPD = 114 Pregestational Diabetes = 32 Hypertension = 51 Cardiovascular disease = 11 Chronic renal disease = 3 Chronic liver disease = 5 Thyroid disease = 32 Neurocognitive disorder = 25 Neuromuscular disorder = 3 Seizure disorder = 10 Inflammatory bowel disease = 3 |
Viktoriya London 2020 [22] | Retrospective Cohort study | Brooklyn, NY, United States of America From March 15th to April 10th 2020 | Maimonades Medical Centre | Total = 68 Symp = 46 Asymp = 22 | Mean age = 30 BMI = 31 Gestational age = all in 3rd trimester (except 17wks (n = 1), 25 wks (n = 1) and 26 wks (n = 1) Nulliparity = 12 | Mean age = 30.5 BMI = 31.6 Gestational age = all third trimester Nulliparity = 8 | Comorbidity = 15/46 Preeclampsia = 2 |
Xiaolin Hu 2020 [25] | Case series | Wuhan, China Jan 20th to Feb 20th | Tongji Medical college | Total = 7 Symp = 6 Asymp = 1 | 32.7 + − 1.6 Gestational Age = 39 + 1 | 33 Gestational age = 38 + 2 | N/A |
Xiaoqing Wu 2020 [24] | Case series | Wuhan, China Dec 31st to March 17th 2020 | Central Hospital of Wuhan | Total 19 Symp = 7 Asymp = 12 | Mean age = 28.3 | Mean age = 29.1 | Hepatitis B = 1 PIH = 0 Hypothyroid = 0 |
Study and year | Past Medical History | Management | Delivery and Neonatal Characteristics and Outcomes | Complications | |||
---|---|---|---|---|---|---|---|
Asymptomatic | Symptomatic | Asymptomatic | Symptomatic | Asymptomatic | Symptomatic | Asymptomatic | |
Dongmei Cao 2020 [23] | Comorbid = none | N/A | N/A | Vaginal birth = 1 Total CD = 6 Elective CD = 4 Intrapartum = 2 Livebirths = 7/7 Birthweight = 3112.14 Neonatal asphyxia = 0 Preterm birth = 2 1 min Apgar score = 8.7 5 min Apgar score = 10 Neonatal death = 0 Neonatal PCR = all negative | Vaginal birth = 1 Total CD = 2 Elective CD = 2 Intrapartum CD = 0 Livebirths = 4/3 (single pair of twins) Birthweight = 3215 Neonatal asphyxia = 0 Preterm birth =1(twins) 1 min Apgar score = 8.3 5 min Apgar score = 10 Neonatal death = 0 Neonatal PCR = all negative | GDM = 1 Pre-eclampsia = 3 Placental abruption = 1 Fetal distress = 1 PROM = 2 Preterm = 2 Neonatal death = 0 | GDM = 0 Pre-eclampsia = 0 Placental abruption = 0 Fetal distress = 1 PROM =2 Preterm- = 1 Neonatal death = 0 |
Ensiyeh Jenabi, 2020 [26] | Comorbidity disease = 19 | N/A | N/A | Preterm labour = 12 C-section = 27 LBW = 12 Neonatal death = 2 | Preterm labour = 6 C-section = 12 LBW = 4 Neonatal death = 1 | Preeclampsia = 11 | Preeclampsia = 4 |
Gabrielle Saccone 2020 [17] | N/A | N/A | N/A | C-section = 100/177 Mean birthweight = 2821 ± 846 IUGR = 9/189 Admission to NICU = 50/177 LBW = 43/177 Neonatal Death = 5/177 | C-section = 36/74 Mean birthweight = 3149 ± 496 IUGR = 1/77 Admission to NICU = 19/74 LBW = 9/74 Neonatal death = 0/74 | Maternal ICU admission = 42/294 Mechanical ventilation = 35/294 | Maternal ICU admission = 1/94 Mechanical ventilation = 1/94 |
Jayasree Santhosh2020 [18] | Hypertension = 2 Diabetes = 3 GDM = 3 Hematologic disease = 1 | N/A | N/A | Normal Vaginal = 19 Instrumental delivery = 1 Elective C-section = 4 Emergency C-section = 12 Preterm birth = 12 Stillbirth = 1 LBW = 9 | Normal Vaginal = 5 Instrumental delivery = 3 Elective C-section = 2 Emergency C-section = 3 Preterm birth = 6 Stillbirth = 0 LBW = 6 | Preterm PROM = 1 Miscarriage = 1 | Preterm PROM = 0 Miscarriage = 0 |
Nicola Vousden2021 [19] | Asthma = 28 Hypertension = 2 Cardiac disease = 8 Diabetes = 6 | Oseltamivir = 11 Steroids = 120 | N/A | C-section = 314 Vaginal = 308 Preterm birth (< 37 weeks) = 114 Stillbirth = 5 Live birth = 627 NICU admission = 121 Neonatal death = 2 | C-section = 153 Vaginal = 228 Stillbirth = 4 Live birth = 381 NICU admission = 35 Neonatal death = 2 | Required critical care = 63 COVID-19 pneumonia = 173 Pre-eclampsia = 15 Death = 8 | N/A |
Sourabh Verma, 2020 [20] | Asthma = 6 Diabetes = 2 Gestational Diabetes = 5 Gestational hypertension = 5 | N/A | N/A | Alive = 89 C-section = 23 Preterm birth (< 37 weeks) = 14 NICU admission = 17 Neonatal death = 1 Positive neonatal RT-PCR = 1/66 | Alive = 60 C-section = 13 Preterm birth (< 37 weeks) = 2 NICU admission = 1 Neonatal death = 0 Positive neonatal RT-PCR = 0/21 | ICU admission = 8 | ICU admission = 9 |
Torri Metz 2021 [21] | Asthma or COPD = 51 Pregestational Diabetes = 17 Hypertension = 29 Cardiovascular disease = 3 Chronic renal disease = 0 Chronic liver disease = 1 Thyroid disease = 22 Neurocognitive disorder = 10 Neuromuscular disorder = 1 Seizure disorder = 4 Inflammatory bowel disease = 0 | N/A | N/A | C-section = 253 Preterm birth (< 37 weeks) = 135 Live births = 626 SGA = 70 Birthweight = 3.5 NICU admission = 163 | C-section = 197 Preterm birth (less than 37 weeks) = 69 Live births = 570 SGA = 56 Birthweight = 3.2 NICU admission = 91 | Maternal death = 6 Venous thromboembolism = 9 Maternal ICU admission = 56 Postpartum hemorrhage = 66 Hypertensive disorder of pregnancy = 176 Neonatal death = 3 | Maternal death = 0 Venous thromboembolism = 0 Maternal ICU admission = 3 Postpartum hemorrhage = 42 Hypertensive disorder of pregnancy = 109 Neonatal death = 2 |
Viktoriya London 2020 [22] | Comorbidity = 4/22 Preeclampsia = 1 | Hydroxychloroquine and azithromycin = 16 Respiratory support = 12 [nasal cannula (n = 7); nonrebreather mask (n = 3); Hi-flow nasal cannula (n = 1); Mechanical ventilation (n = 1) | Hydroxychloroquine and azithromycin = 0 Respiratory support = 0 | C-section = 16 Preterm < 37 wks = 9 Preterm < 34 wks = 3 Preterm due to: maternal respiratory distress (n = 7); decreased fetal movements (n = 1) | C-section = 6 Preterm < 37 wks = 0 Preterm < 34 wks = 0 | N/A | N/A |
Xiaolin Hu 2020 [25] | N/A | Anti-viral = 1 | Anti-viral = 0 | SVD = 1 C-section = 5 Birthweight = 3356.67 1 min Apgar = 8 5 min Apgar = 9 COVID RT-PCR = 1 positive | SVD = 0 C-section = 1 Birthweight = 3180 1 min APGAR = 7 5 min APGAR = 8 Covid RT-PCR = all negative | Liver dysfunction | No complications |
Xiaoqing Wu 2020 [24] | Hepatitis B = 1 PIH = 3 Hypothyroid = 1 | N/A | N/A | N/A | N/A | PROM = 0 Fetal intrauterine hypoxia = 0 | PROM = 1 Fetal intrauterine hypoxia = 1 |