Fig. 1

A Pedigree of a Chinese prenatal case with auriculocondylar syndrome (ACS). The proband, an affected fetus, is depicted as a filled diamond and indicated by a black arrow. B Recording of the amniotic fluid indexes (AFIs) measured by ultrasonography. The median, upper 95th, and upper 99th percentiles of AFI in normal singleton pregnancy are plotted as solid, dashed, and dotted lines, respectively (data from Moore & Cayle, [9]). The AFIs of this case are indicated by red crosses and the single deepest pockets (SDPs) are also presented accordingly. C Craniofacial features of the affected fetus visualized by ultrasonography at 29 weeks of gestation. D Craniofacial features of the affected fetus visualized by ultrasonography at 29 weeks and 6 days of gestation. The mandibular hypoplasia (severe micrognathia, retrognathia, short and vertical mandibular ramus, linear configuration of the mandibular body, and loss of mandibular angle) is indicated by white arrows; the low-set ears are indicated by white arrows; the round face is indicated by blue arrows