Fig. 4

Concentrations of Monocyte trafficking- and Th17 response, B cell, DC homing to gut-associated lymphoid tissue-related chemokines in the ANX, ANX + DEP and CTRL groups. The figures depict the values of the serum estimated concentrations of Monocyte trafficking-related chemokine, MCP-1/CCL2 (A) and the Th17 response, B cell, DC homing to gut-associated lymphoid tissue-related chemokine, MIP-3α/CCL20 (B) in the CTRL, ANX, and ANX + DEP groups. These immune mediators (Monocyte trafficking- and Th17 response, B cell, DC homing to gut associated lymphoid tissue- chemokines) were quantified by flow cytometry. The concentration values are expressed as the mean ± SEM. The parametric, t-test analysis with Welch’s correction was used to estimate the p values for each functional chemokine assayed in the study among the tested groups. (*) p < 0.05; (**); p < 0.001; (***) p < 0.0001. ANX + DEP, high anxiety plus comorbid depression; ANX, high anxiety; CTRL, control. Data were calculated using GraphPad v.7