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Table 3 Unadjusted and adjusted odds ratios for prediction of adverse pregnancy outcome of MAMAS participants

From: A prospective cohort study providing insights for markers of adverse pregnancy outcome in older mothers

 

Normal Outcome (n = 420) (N(%))

Adverse Outcome (n = 108) (N(%))

Unadjusted

Model 1

Model 2

OR (95% CI)

P value

AOR (95% CI)

P value

AOR

P value

Ethnicity

 European

373 (89)

101 (94)

Reference

 

Reference

 

Reference

 

 Asian

24 (6)

5 (5)

0.77 (0.29–2.07)

0.49

0.73 (0.25–2.13)

0.57

0.58 (0.18–1.88)

0.37

 Other

23 (5)

2 (2)

0.32 (0.74–1.38)

0.08

0.27 (0.06–1.28)

0.081

0.27 (0.54–1.32)

0.11

Parity

 Nulliparous

143 (34)

47 (44)

Reference

 

Reference

 

Reference

 

 Multiparous

277 (66)

61 (56)

0.67 (0.44–1.03)

0.07

0.58 (0.36–0.93)

0.03

0.56 (0.33–0.89)

0.02

ART

 None

383 (91)

99 (92)

Reference

 

Reference

 

Reference

 

 ART

37 (9)

9 (8)

0.94 (0.44–2.01)

0.88

1.01 (0.44–2.29)

0.99

0.85 (0.35–2.04)

0.71

Smoking

 No

332 (79)

66 (61)

Reference

 

Reference

 

Reference

 

 Ex

69 (16)

27 (25)

1.96 (1.17–3.30)

0.01

1.86 (1.08–3.24)

0.03

1.85 (1.05–3.25)

0.03

 Current

19 (5)

15 (14)

3.97 (1.92–8.21)

< 0.001

4.24 (1.88–9.54)

< 0.001

4.22 (1.83–9.75)

0.001

Housing

 Rented

123 (29)

45 (42)

Reference

 

Reference

 

Reference

 

 Owns

297 (71)

63 (58)

0.58 (0.37–0.90)

0.01

0.57 (0.34–0.97)

0.04

0.56 (0.32–0.98)

0.04

IMD Quintile

 1st

73 (18)

19 (18)

Reference

 

Reference

 

Reference

 

 2nd

78 (20)

29 (27)

1.42 (0.74–2.74)

0.29

1.31 (0.66–2.60)

0.53

1.37 (0.68–2.76)

0.38

 3rd

97 (24)

13 (12)

0.51 (0.24–1.11)

0.09

0.46 (0.21–101)

0.05

0.48 (0.21–1.10)

0.08

 4th

68 (17)

21 (20)

1.19 (0.59–2.40)

0.63

0.92 (0.44–1.93)

0.82

0.98 (0.46–2.10)

0.97

 5th

82 (21) 22 missing values

14 (23) 2 missing values

1.12 (0.57–2.22)

0.74

0.98 (0.46–2.08)

0.96

1.02 (0.48–2.23)

0.94

Paternal Age

 < 30 years

86 (21)

33 (32)

Reference

   

Reference

 

 30–34 years

58 (14)

16 (15)

0.77 (0.39–1.51)

0.45

  

0.86

0.72

 35–39 years

115 (28)

24 (23)

0.54 (0.30–0.98)

0.04

  

0.54

0.16

 ≥40 years

148 (36)

13 missing values

31 (90)

4 missing values

0.54 (0.31–0.94)

0.03

  

0.46

0.08

  1. Model 1 – multivariable logistic regression including all variables except paternal age (ethnicity, parity, smoking, house ownership, IMD quintile and maternal age group), Model 2 – multivariable regression additionally adjusting for paternal age. ART Assistive Reproductive Techniques, IMD Index of multiple deprivation, IMD Quintile 1st = least deprived, 5th = most deprived. Statistics performed were univariate and multivariable meta-regression. Adjustments included maternal ethnicity, parity, smoking status, housing, and paternal age