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Table 7 The probabilities and area of ROC of multi-markers, dual of estradiol and progesterone, estradiol and progesterone using logistic regression and ROC analyze

From: Prediction of miscarriage in first trimester by serum estradiol, progesterone and β-human chorionic gonadotropin within 9 weeks of gestation

Markers

Probabilities of miscarriage

P

Area of ROC

P

Cutoff value

E2+P+β-HCG (7-9 weeks)

92.9

0.001**

0.869(0.759-0.980)

0.000**

 

E2+P (7-9 weeks)

73.8

0.000**

0.871 (0.793-0.950)

0.000**

 

E2+β-HCG (7-9weeks)

92.9

0.005**

0.795(0.641-0.948)

0.000**

 

P+β-HCG(7-9weeks)

82.1

0.000**

0.865(0.760-0.968)

0.000**

 

E2 (7-9 weeks)

85.7

0.000**

0.866 (0.793- 0.938)

0.000**

576pg/ml

P (7-9 weeks)

68.2

0.000**

0.766(0.672- 0.861)

0.000**

15.27ng/ml

β-HCG(7-9weeks)

-

0.087#

0.661

0.059#

3098.765IU/L

E2+P+β-HCG (5-6weeks)

80.4

0.000**

0.768 (0.670-0.866)

0.000**

 

E2+P (5-6 weeks)

80.4

0.012**

0.739(0.651-0.827)

0.000**

 

E2+β-HCG(5-6weeks)

86.3

0.000**

0.770(0.672-0.869)

0.000**

 

P+β-HCG(5-6weeks)

73.6

0.03*

0.667(0.561-0.772)

0.004**

 

E2 (5-6 weeks)

72.7

0.000**

0.709(0.616-0.801)

0.000**

320pg/ml

P (5-6 weeks)

28.1

0.046#

0.529

0.572#

8.47ng/ml

β-HCG (5-6 weeks)

-

1.050#

0.396

0.059#

2858.6IU/L

  1. *, **Significantly prediction utility for miscarriage (*P<0.05, **P<0.01)
  2. # No significantly prediction utility for miscarriage
  3. E2 estradiol, P progesterone, E2+P+ β-HCG multi markers analysis