Maternal exposure to life events during pregnancy and congenital heart disease in offspring: a case-control study in a Chinese population

Table 3 The dose-response association between frequency of life events and CHD in offspring

Frequency	Case group	Control group	OR (95%CI) ^a		p for trend
Frequency	(n = 699)	(n = 1581)	Unadjusted	Adjusted	p for trend
Positive events
0	539 (77.11)	889 (56.23)	1.00	1.00	<0.001
1	121 (17.31)	524 (33.14)	0.35(0.27, 0.44) ^**	0.37 (0.28, 0.48) ^**
≥2	39 (5.58)	168 (10.63)	0.26(0.17, 0.38) ^**	0.34 (0.21, 0.53) ^**
Negative events
0	402 (57.51)	1029 (65.09)	1.00	1.00	<0.001
1~2	196 (28.04)	422 (26.69)	1.42(1.15, 1.76) ^*	1.40 (1.09, 1.79) ^*
3~4	55 (7.87)	84 (5.31)	2.32(1.58, 3.39) ^**	2.08 (1.34, 3.25) ^*
≥5	46 (6.58)	46 (2.91)	4.36(2.73, 6.96) ^**	3.15 (1.82, 5.43) ^**

^aLogistic model was used for estimating risk of life events with or without adjusting for covariates. Adjusted covariates included maternal age, residence, maternal education, paternal education, family history of CHD, history of parturition, history of abortion, infection during periconception, and abnormal prenatal examination
^* p < 0.01; ^** p < 0.001

ISSN: 1471-2393