Plasma fibulin-1 levels during pregnancy and delivery: a longitudinal observational study

Table 2 Estimated differences in plasma fibulin-1 concentrations between various subgroups of participants

Parameter		β-estimate (μg/mL)^a	SE ^b	p-value ^c
Intercept		31.9	11.2	0.004 **
Age	Per 1-year increase	0.2	0.3	0.4
Parity	0	Reference
	1	2.6	2.2	0.2
	2+	4.9	3.2	0.1
Body mass index	Per 1-unit increase (kg/m²)	-0.3	0.3	0.3
Smoking habits	Non-smoker	Reference
Smoking habits	Smoker	-5.2	2.3	0.02 *
Mode of conception	Spontaneous	Reference
	In-vitro fertilization	0.4	10.3	1.0
	Insemination	-18.1	9.5	0.06
Gestational weeks	12-20	Reference
	21-28	0.9	1.4	0.5
	29-34	5.6	1.7	<0.001 ***
	35-42	12.5	1.6	<0.001 ***
	Delivery	4.1	1.5	0.005 **
	1^st day after delivery	-1.3	1.5	0.4
	2^nd day after delivery	-3.4	1.5	0.002 *
Pre-eclampsia	Not present	Reference
Pre-eclampsia	Present	-0.2	3.0	0.9
PPROM	Not present	Reference
PPROM	Present	-11.6	4.2	0.006 **
Mode of delivery	Vaginal birth	Reference
	Elective caesarean section	-7.0	2.3	0.002 **
	Emergency caesarean section	-5.6	2.9	0.05 #
Bleeding at delivery	Per 100mL increase	-0.03	0.4	0.9
Birth weight	Per 100grams increase	-0.08	0.2	0.7

^a Estimated slope coefficient using a linear mixed model and fitted with the restricted maximum likelihood approach. Tukey’s test was used for multiple comparisons of means. ^b Standard error. ^c Compared to the reference level of the variable, adjusted for all other variables in the table. Significance levels ‘***’0.001, ‘**’0.01, ‘*’0.05, ‘#’ 0.1

ISSN: 1471-2393