Does women’s place of birth affect their opportunity for an informed choice about Down syndrome screening? A population-based study in France

Table 2 Down syndrome screening according to mother's place of birth (years: 2010+2016)

	Total n=24 644 %	France n=20 612 %	Europe n=861 %	North Africa n=1550 %	Sub-Saharan Africa n=960 %	Other countries n=661 %	p
Did you have fetal nuchal translucency measured at your first-trimester ultrasound to learn your risk of Down syndrome ?
No	5.6	4.6	6.4	13.6	11.5	9.3
Yes	86.5	90.3	76.3	62.6	62.4	72.3
I don't know	7.9	5.2	17.3	23.8	26.1	18.4
							<0.001
Did you have a blood test to learn your risk for Down syndrome?
No	11.3	9.5	14.8	28.0	20.3	11.1
Yes	86.4	89.5	77.9	62.7	69.0	79.8
I don't know	2.4	1.1	7.2	9.3	10.7	9.1
							<0.001
If not, why didn't you have this blood test?
not offered	11.6	11.4	12.5	12.5	12.4	8.3
I refused	49.2	47.9	50.0	58.3	43.2	46.7
prenatal care was: too late/or none/or abroad	21.9	22.4	15.2	18.3	27.0	28.3
amniocentesis or chorionic villus sampling first	7.0	8.8	9.8	1.5	0.60	3.3
other reason	5.5	6.5	2.7	1.8	6.2	1.7
I don't know	4.7	2.9	9.8	7.6	10.7	11.7
							<0.001
Opportunity to make an informed choice^a
Yes	93.0	95.1	87.2	79.9	78.4	86.0
No	7.0	4.9	12.8	20.1	21.6	14.0
							<0.001

^aAnswer "yes" if the serum marker assay was performed or refused, or if amniocentesis or a chorionic villus sampling was performed first. Answer "no" if the answer to the question "did you have a blood test to learn your risk of Down syndrome (serum markers)?" was "I don't know" or if the assay was not performed for one of the following reasons: not offered, because of late prenatal care, for another reason, or for an unknown reason (see Fig. 1)

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