Does women’s place of birth affect their opportunity for an informed choice about Down syndrome screening? A population-based study in France

Table 1 Comparison in Down syndrome screening between 2010 and 2016

	2010 %	2016 %	2010 + 2016 (n) %	p
Did you have fetal nuchal translucency measured at your first-trimester ultrasound to learn your risk of Down syndrome?			(24 592)
No	5.6	5.7	5.6
Yes	85.1	88.2	86.5
I don't know	9.3	6.2	7.9
				<0.001
Did you have a blood test to learn your risk for Down syndrome (serum markers)?			(24 484)
No	12.7	9.5	11.3
Yes	84.7	88.4	86.4
I don't know	2.6	2.1	2.4
				<0.001
If not, why didn't you have this assay?			(2 543)
not offered	14.2	6.8	11.6
I refused	44.0	59.1	49.2
prenatal care was: too late/or none/ or abroad	21.4	22.9	21.9
amniocentesis or chorionic villus sampling	9.7	2.2	7.0
other reason	5.6	5.2	5.5
I don't know	5.2	3.8	4.7
				<0.001
Opportunity to make an informed choice^a			(24 265)
Yes	91.7	94.7	93.0
No	8.4	5.3	7.0
				<0.001

^a Answer "yes" if the serum marker assay was performed or refused, or if amniocentesis or a chorionic villus sampling was performed first. Answer "no" if the answer to the question "did you have a blood test to learn your risk of Down syndrome (serum markers)?" was "I don't know" or if the assay was not performed for one of the following reasons: not offered, because of late prenatal care, for another reason, or for an unknown reason (see Fig. 1)

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