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Table 2  Multivariable regression of factors associated with Respiratory Distress Syndrome development

From: Do maternal demographics and prenatal history impact the efficacy of betamethasone therapy for threatened preterm labor?

 

Adjusted Odds Ratios (CI)a

 

Overall Cohort

<14 Daysb

<7 Days

2-7days

Only 1 course

N

209

101

83

27

171

Maternal Age

1.01 (1.00-1.02)

1.01 (0.99-1.02)

1.01 (1.00-1.02)

1.01 (0.98-1.04)

1.00 (0.99-1.01)

Maternal BMIc at Dosing

1.00 (0.99-1.01)

1.00 (0.99-1.01)

1.00 (0.99-1.01)

1.00 (0.98-1.02)

1.00 (0.99-1.01)

Maternal Ethnicity, Hispanic

1.08 (0.95-1.22)

1.09 (0.89-1.32)

1.09 (0.88-1.35)

1.06 (0.71-1.57)

1.03 (0.91-1.17)

Maternal Race

 White or Caucasian

Reference

Reference

Reference

Reference

Reference

 Black or African American

0.99 (0.90-1.09)

0.97 (0.81-1.17)

0.97 (0.81-1.17)

0.87 (0.62-1.21)

0.97 (0.88-1.07)

 Other

0.89 (0.71-1.11)

0.76 (0.50-1.16)

0.76 (0.50-1.16)

0.49 (0.20-1.19)

0.90 (0.73-1.10)

Maternal Tobacco Use

1.03 (0.93-1.15)

1.04 (0.86-1.24)

1.05 (0.86-1.29)

1.23 (0.86-1.76)

1.03 (0.93-1.15)

Diabetes

0.92 (0.80-1.05)

1.03 (0.82-1.30)

1.12 (0.87-1.44)

1.08 (0.60-1.95)

0.92 (0.79-1.06)

Preeclampsia

1.07 (0.96-1.19)

1.08 (0.91-1.28)

1.04 (0.86-1.25)

1.05 (0.72-0.53)

1.06 (0.94-1.19)

Chronic Hypertension

1.06 (0.95-1.19)

1.09 (0.91-1.31)

1.08 (0.89-1.32)

1.22 (0.83-1.77)

1.11 (0.99-1.25)

PPROMd

0.91 (0.78-1.06)

0.81 (0.67-0.99)

0.85 (0.68-1.08)

0.82 (0.56-1.20)

0.89 (0.76-1.04)

Days Between Last BMZf Dose and Delivery

1.00 (1.00-1.00)

1.00 (0.98-1.02)

0.99 (0.94-1.04)

1.02 (0.91-1.16)

1.00 (1.00-1.00)

Total Doses of BMZ

1.06 (0.99-1.13)

1.01 (0.92-1.12)

1.00 (0.89-1.11)

1.14 (0.91-1.41)

0.83 (0.66-1.05)

Delivery Type

 Vaginal

Reference

Reference

   

 Cesarean without labor

1.14 (1.03-1.27)

1.13 (0.96-1.34)

1.14 (0.95-+1.38)

1.45 (1.07-1.98)

1.14 (1.03-1.27)

 Cesarean with labor

1.25 (1.07-1.46)

1.42 (1.13-1.79)

1.36 (1.05-1.78)

2.08 (1.16-3.72)

1.24 (1.02-1.50)

  1. aOdds ratios of maternal and prenatal factors by multivariable regression with adjustment for GA at delivery
  2. bThe subcohort refers to women who delivered within 14 days of receiving their last BMZ dose
  3. cBody mass index (BMI) reported in kg/m2
  4. dPreterm premature rupture of membranes (PPROM)
  5. eGestational age (GA)
  6. fBetamethasone (BMZ)