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Table 2 Diagnoses Among Infertile Couples Before and After Natural Procreative Technology Evaluation (n=370)a

From: Restorative reproductive medicine for infertility in two family medicine clinics in New England, an observational study

Diagnostic Category

Before NPT Evaluation, n (%)

After NPT Evaluation, n (%)

P Value

Unexplained infertility

86 (23)

2 (1)

<.0001

Pregnant before evaluation completed

1 (0)

NA

NA

Male factor

36 (10)

110 (30)

<.0001

Endometriosis

50 (14)

275 (74)

<.0001

Blocked fallopian tubes

18 (5)

56 (15)

<.0001

Pelvic adhesions

16 (4)

89 (24)

<.0001

Polycystic ovarian syndrome

34 (9)

73 (20)

<.0001

Ovarian dysfunction

NA

246 (66)

NA

 Anovulation

4 (1)

25 (7)

<.0001

 Low periovulatory estrogen

NA

130 (35)

NA

 Low luteal estrogen

1 (0)

60 (16)

<.0001

 Low luteal progesterone

14 (4)

208 (56)

<.0001

Limited cervical mucus

7 (2)

241 (65)

<.0001

Hypothyroidism

24 (6)

37 (10)

0.037

Fibroids

21 (6)

32 (9)

0.048

Premenstrual syndrome

NA

161 (44)

NA

Abnormal vaginal bleeding

NA

70 (19)

NA

Mental health diagnosis, femaleb

NA

93 (25)

NA

Diminished ovarian reserve

NA

45 (12)

NA

Sexual dysfunction, female or male

NA

46 (13)

NA

Elevated prolactin in female

NA

18 (5)

NA

Vitamin D deficiency

NA

53 (14)

NA

  1. NA not applicable or not available, NPT Natural Procreative Technology
  2. aMost couples had multiple diagnoses (mean number of diagnoses, 4.9; SD, 2.3; range, 0-14)
  3. bPrimarily depression