Assisted reproductive technology and hypertensive disorders of pregnancy: systematic review and meta-analyses

Table 2 Summary of results by type of ART and outcome of interest

Experimental	Number of studies	ART study size (n)	SC study size (n)	OR; 95% CI	I² (%)	P value	NNH (n)
Hypertensive Disorders of Pregnancy
IVF/ICSI singleton	51	268,166	7,728,641	1.70 (1.60–1.80)	80	< 0.01^a	47.2
IVF singleton	5	41,238	437,723	1.55 (1.23–1.94)	90	< 0.01^a	85.9
ICSI singleton	9	27,108	446,149	1.52 (1.28–1.80)	75	< 0.01^a	54.3
IVF/ICSI multiple	41	88,853	120,396	1.34 (1.20–1.50)	76	< 0.01^a	47.8
IVF multiple	4	13,147	73,297	1.13 (0.98–1.29)	59	0.09	86.3
ICSI multiple	10	9924	77,179	1.11 (0.91–1.36)	77	0.30	12.8
Fresh embryo transfer singleton	16	162,867	4,381,981	1.43 (1.33–1.53)	72	< 0.01^a	57.4
Frozen embryo transfer singleton	9	41,462	4,090,152	1.74 (1.58–1.92)	55	< 0.01^a	52.6
Oocyte donation singleton	9	12,461	2,413,466	4.42 (3.00–6.51)	83	< 0.01^a	16.3
Oocyte donation multiple	2	10,488	59,045	2.62 (2.46–2.79)	0	< 0.01^a	10.2
Preeclampsia
IVF/ICSI singleton	28	118,787	4,509,905	1.59 (1.46–1.74)	70	< 0.01^a	81.0
ICSI singleton	2	5807	31,124	0.98 (0.38–2.51)	72	0.97	105.2
IVF/ICSI multiple	17	14,842	34,337	1.24 (1.08–1.43)	32	< 0.01^a	91.7
IVF multiple	2	5696	25,998	1.04 (0.93–1.16)	0	0.47	364.0
ICSI multiple	5	5618	29,519	1.11 (1.00–1.24)	0	0.05^a	52.1
Fresh embryo transfer singleton	8	55,300	2,715,647	1.48 (1.37–1.60)	39	< 0.01^a	85.5
Frozen embryo transfer singleton	5	19,216	2,699,693	1.82 (1.71–1.95)	0	< 0.01^a	45.6
Oocyte donation singleton	7	1107	1,031,110	5.20 (4.02–6.73)	9	< 0.01^a	10.1

ISSN: 1471-2393