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Table 2 Summary of results by type of ART and outcome of interest

From: Assisted reproductive technology and hypertensive disorders of pregnancy: systematic review and meta-analyses

Experimental Number of studies ART study size (n) SC study size (n) OR; 95% CI I2 (%) P value NNH (n)
Hypertensive Disorders of Pregnancy
 IVF/ICSI singleton 51 268,166 7,728,641 1.70 (1.60–1.80) 80 < 0.01a 47.2
 IVF singleton 5 41,238 437,723 1.55 (1.23–1.94) 90 < 0.01a 85.9
 ICSI singleton 9 27,108 446,149 1.52 (1.28–1.80) 75 < 0.01a 54.3
 IVF/ICSI multiple 41 88,853 120,396 1.34 (1.20–1.50) 76 < 0.01a 47.8
 IVF multiple 4 13,147 73,297 1.13 (0.98–1.29) 59 0.09 86.3
 ICSI multiple 10 9924 77,179 1.11 (0.91–1.36) 77 0.30 12.8
 Fresh embryo transfer singleton 16 162,867 4,381,981 1.43 (1.33–1.53) 72 < 0.01a 57.4
 Frozen embryo transfer singleton 9 41,462 4,090,152 1.74 (1.58–1.92) 55 < 0.01a 52.6
 Oocyte donation singleton 9 12,461 2,413,466 4.42 (3.00–6.51) 83 < 0.01a 16.3
 Oocyte donation multiple 2 10,488 59,045 2.62 (2.46–2.79) 0 < 0.01a 10.2
Preeclampsia  
 IVF/ICSI singleton 28 118,787 4,509,905 1.59 (1.46–1.74) 70 < 0.01a 81.0
 ICSI singleton 2 5807 31,124 0.98 (0.38–2.51) 72 0.97 105.2
 IVF/ICSI multiple 17 14,842 34,337 1.24 (1.08–1.43) 32 < 0.01a 91.7
 IVF multiple 2 5696 25,998 1.04 (0.93–1.16) 0 0.47 364.0
 ICSI multiple 5 5618 29,519 1.11 (1.00–1.24) 0 0.05a 52.1
 Fresh embryo transfer singleton 8 55,300 2,715,647 1.48 (1.37–1.60) 39 < 0.01a 85.5
 Frozen embryo transfer singleton 5 19,216 2,699,693 1.82 (1.71–1.95) 0 < 0.01a 45.6
 Oocyte donation singleton 7 1107 1,031,110 5.20 (4.02–6.73) 9 < 0.01a 10.1
  1. a= Statistically significant. NNH Numbers needed to harm