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Table 1 Characteristics of 78 included cohort studies. S = Singleton pregnancy, M = Multiple pregnancy

From: Assisted reproductive technology and hypertensive disorders of pregnancy: systematic review and meta-analyses

First author, Publication year, Country Type of cohort Years of the cohort Matching factors Comparison groups Pregnancies conceived by IVF/ICSI (n) Spontaneous pregnancies (n) NOS Score
Agarwal, 2005, Singapore [24] Hospital-based Retrospective 1998–1999 Maternal age, sex, date of delivery, race, plurality and parity IVF/ICSI, ICSI alone (S) 41
(M) 35
(S) 147
(M)114
7
Ai, 2005, China [25] Hospital-based Retrospective 1998–2004 No IVF/ICSI (M) 47 (M) 98 6
Apantaku, 2008, UK [26] Hospital-based Retrospective 1999–2004 Maternal age, parity IVF/ICSI (S) 88 (S) 88 8
Aydin, 2016, Turkey [27] Hospital-based Retrospective 2007–2010 Maternal age IVF/ICSI (M)137 (M) 133 8
Barda, 2017, Israel [28] Hospital-based Retrospective 2009–2015 No IVF/ICSI (M) 449 (M) 259 6
Barua, 2016, Australia [29] Hospital-based Retrospective 2007–2010 No IVF/ICSI, ICSI alone (S) 470 (S) 48654 6
Beltran Anzola, 2019, France [30] Hospital-based Retrospective 1995–2015 Maternal age, exact year of birth, parity, sex IVF/ICSI, Fresh embryo transfer, Frozen embryo transfer (S) 2327 (S) 6981 7
Bensdorp, 2016, Netherlands [31] (a) Population-based Retrospective 2000–2012 Zygosity, parity, socioeconomic status, conception method IVF/ICSI, ICSI alone (M) 2437 (M) 3276 7
Beyer, 2016, Germany [32] Hospital-based Retrospective N/A (13-year period) No IVF/ICSI, Fresh embryo transfer, Frozen embryo transfer (S) 467 (S) 6417 6
Carbone, 2011, UK [33] Hospital-based Prospective 2006–2009 No IVF/ICSI (S) 426 (S) 26538 7
Caserta, 2008, Italy [34] Hospital-based
Prospective
2004–2006 Parity, age, height, weight, ethnic origin, smoking, history of infertility IVF/ICSI, ICSI alone (S) 364 (S) 304 3
Caserta, 2014, Italy [35] Hospital-based Retrospective 2007–2011 No IVF/ICSI (M) 138 (M) 207 7
Choi, 2006, Korea [36] Hospital-based Retrospective 1994–2003 No IVF/ICSI (M) 190 (M) 347 6
Daniel, 2000, Israel [37] Hospital-based Retrospective 1996–1997 No IVF/ICSI (M) 104 (M) 121 7
Dayan, 2015, Canada [38] Hospital-based Retrospective 2001–2008 No IVF/ICSI (S) 326 (S) 9175 7
Dayan, 2016, Canada [39] Population-based Retrospective 2006–2012 No IVF/ICSI (S) 5371 (S) 795997 7
Dayan, 2018, Canada [40] Population-based Retrospective 2013–2014 No IVF/ICSI (S) 1596 (S) 112813 6
Deltombe-Bodart, 2017, France [41] Hospital-based Retrospective 1997–2014 No IVF/ICSI, ICSI alone (M) 360 (M) 986 6
Dior, 2018, Israel [42] Hospital-based Retrospective 1995–2012 No Oocyte Donation (S) 135 (S) 270 7
Elenis, 2015, Sweden [43] Population-based Retrospective 2005–2008 Age IVF/ICSI, Oocyte Donation (S) 139 (M) 150 7
Ernstad, 2019, Sweden [44] Population-based Retrospective 2005–2015 No IVF/ICSI, Fresh embryo transfer (S) 34091 (S) 1127566 6
Fan, 2013, China [45] Hospital-based Retrospective 2010–2013 No IVF/ICSI, ICSI alone (M) 162 (M) 213 7
Farhi, 2013, Israel [46] Hospital-based Prospective 2006–2008 No IVF/ICSI, ICSI alone (S) 509 (S) 587 5
Geipel, 2001, Germany [47] Hospital-based Retrospective 1995–1999 Maternal age, parity, plurality IVF/ICSI, ICSI alone (S) 114
(M) 32
(S) 114
(M) 32
8
Gocmen, 2015, Turkey [48] Hospital-based Retrospective 2011–2014 No IVF/ICSI (M) 19 (M) 65 8
Gojnic, 2005, Serbia [49] N/A N/A Age, education, parity IVF/ICSI (M) 120 (M) 120 2
Hessami, 2020, Iran [50] Hospital-based Retrospective 2013–2018 No IVF/ICSI (M) 202 (M) 449 6
Howe, 1990, US [51] Hospital-based Retrospective N/A (first 100 clinical pregnancies conceived in the IVF program) Age, race, parity, pre-existing medical problem, DES exposure, insurance status IVF/ICSI (S)54 (S)54 7
Jancar, 2018, Slovenia [52] Population-based Retrospective 2002–2015 No IVF/ICSI (S) 5837 (S) 261881 7
Jeve, 2016, UK [53] Hospital-based Retrospective 2007–2014 Age IVF/ICSI, Oocyte donation (S) 90 (S) 45 8
Katalinic, 2004, Germany [54] Hospital-based Prospective 1998–2000; 1993–2001 (control) No IVF/ICSI, ICSI alone, Fresh embryo transfer (S) 2055
(M) 632
(S) 7861
(M) 77
6
Koivurova, 2002, Finland [55] Population-based Retrospective 1990–1995 Sex of the child, birth year, area of residence, parity, maternal age, social class (defined by occupation) IVF/ICSI, Fresh embryo transfer (S) 153
(M) 62
(S) 580
(M) 82
7
Korosec, 2016, Slovenia [56] Hospital-based Retrospective 2004–2011 Age, parity, hospital IVF/ICSI, Fresh embryo transfer, Frozen embryo transfer (S)1127 (S) 3381 7
Kouhkan, 2018, Iran [57] Hospital-based Prospective 2014–2017 No IVF/ICSI (S) 260 (S) 314 7
Kuivasaari- Pirinen, 2012, Finland [58] Hospital-based Retrospective 1996–2007 No IVF/ICSI (S) 255 (S) 26870 7
Lee, 2015, US [59] Hospital-based Retrospective 2007–2009 No IVF/ICSI (S) 108 (S) 2284 7
Lei, 2019, China [60] Hospital-based Retrospective 2013–2015 No IVF/ICSI (S) 1453
(M) 803
(S) 6667
(M) 101
6
Li, 2015, China [61] Hospital-based Retrospective 2009–2011 No IVF/ICSI (M) 108 (M) 144 6
Luke, 2019, US [62] Population-based Retrospective 2004–2013 (depending on states) No IVF/ICSI, Oocyte donation (M) 58,920 (M) 34,033 7
Luke, 2020, US [63] Population-based Retrospective 2004–2013 (depending on states) No IVF/ICSI, Fresh embryo transfer,
Frozen embryo transfer, Oocyte donation
(S) 83582 (S) 1382311 6
Malchau, 2013, Denmark [64] Population-based Retrospective 1995–2010 Date and year of birth IVF/ICSI, ICSI alone, Oocyte donation (S) 15741
(M) 8564
(S) 31010
(M) 25,012
7
Martinez-Varea, 2015, Spain [65] Hospital-based Prospective N/A No IVF/ICSI, Oocyte donation (S) 50 (S) 25 6
Meyer, 2020, Israel [66] Hospital-based Retrospective 2011–2018 Age Oocyte donation (S) 159 (S) 73 7
Mohammed, 2012, Qatar [67] Hospital-based Retrospective 2002–2011 No IVF/ICSI (M) 145 (M) 175 7
Moini, 2012, Iran [68] Hospital-based Prospective 2008–2010 No IVF/ICSI, ICSI alone (M) 230 (M) 170 6
Nagata, 2019, Japan [69] Population-based Retrospective 2011–2014 No IVF/ICSI, ICSI alone (S) 2993
(M) 129
(S) 88873
(M) 625
7
Nassar, 2003, Lebanon [70] Hospital-based Retrospective 1995–2000 Age, parity IVF/ICSI (M) 56 (M) 112 9
Nejdet, 2016, Sweden [71] Population-based Retrospective 2003–2012 No IVF/ICSI, Fresh embryo transfer, Frozen embryo transfer, Oocyte donation (S) 27084 (S) 999804 7
Ochsenkuehn, 2003, Germany [72] Hospital-based Retrospective 1991–1996 Maternal age, gestational age, parity IVF/ICSI (S) 163
(M) 65
(S) 322
(M) 78
8
Okby, 2018, Israel [73] Population-based Retrospective 1988–2010 No IVF/ICSI (M) 465 (M) 3053 8
Olivennes, 1993, France [74] Hospital-based Retrospective 1987–1989 No IVF/ICSI (S) 162 (S) 5096 6
Opdahl, 2015, Sweden, Denmark, Norway [75] Population-based Retrospective 1988–2007 Parity, birth year IVF/ICSI (S) 47088
(M) 10,918
(S) 268599
(M) 46,674
9
Poikkeus, 2007, Finland [76] Hospital-based Retrospective 1997–2003 Year, place of residence IVF/ICSI, Fresh embryo transfer (S) 499 (S) 15037 7
Qin, 2017, China [77] Hospital-based Prospective 2013–2016 No IVF/ICSI (S) 1260 (S) 2480 6
Raisanen, 2013, Finland [78] Population-based Retrospective 2006–2010 No IVF/ICSI (S) 5647 (S) 285357 7
Reismullerova, 2015, Slovakia [79] Hospital-based Retrospective N/A No IVF/ICSI (S) 526 (S) 15874 7
Reubinoff, 1997, Israel [80] Hospital-based Retrospective 1983–1993 Maternal ethnic origin, age, parity, location and date of delivery IVF/ICSI (S) 260 (S) 260 7
Rizzo, 2016, Italy [81] Hospital-based Prospective 2007–2014 Maternal age IVF/ICSI, Fresh embryo transfer, Frozen embryo transfer (S) 266 (S) 266 9
Rizzo, 2016, Italy [2] [82] Hospital-based Prospective 2007–2014 Maternal age IVF/ICSI, Oocyte donation (S) 109 (S) 498 9
Sazonova, 2012, Sweden [83] Population-based Retrospective 2002–2006 No IVF/ICSI, Fresh embryo transfer, Frozen embryo transfer (S) 11292 (S) 571914 7
Shi, 2018, China [84] Hospital-based Retrospective 2013–2016 No IVF/ICSI (M) 850 (M) 250 5
Shiloh, 2019, Israel [85] Population-based Retrospective 1991–2014 No IVF/ICSI (S) 2603 (S) 237863 6
Silberstein, 2014, Israel [86] Hospital-based Retrospective 1988–2006 No IVF/ICSI (S) 1294 (S) 171513 6
Stojnic, 2013, Serbia [87] Hospital-based Retrospective 2006–2010 Maternal age, parity, education, time and place of delivery, BMI IVF/ICSI, Fresh embryo transfer (S) 634 (S)634 7
Sun, 2009, Canada [88] Population-based Retrospective 2004–2007 Maternal age, parity IVF/ICSI (S) 870 (S) 3433 9
Sun, 2016, China [89] Hospital-based Retrospective 2010–2014 No IVF/ICSI (M) 411 (M) 742 7
Suzuki, 2010, Japan [90] Hospital-based Retrospective 2000–2007 No IVF/ICSI (M) 64 (M) 76 6
Szymusik, 2012, Poland [91] Hospital-based Retrospective 2005–2009 No IVF/ICSI, Fresh embryo transfer (M) 43 (M)83 4
Szymusik, 2018, Poland [92] Hospital-based Prospective 2013–2016 No IVF/ICSI (S) 183 (S) 368 4
Tan, 1992, UK [93] Hospital-based Retrospective 1978–1987 Maternal age IVF/ICSI (S) 494
(M) 125
(S) 978
(M) 21
6
Tandberg, 2015, Norway [94] Population-based Retrospective 1988–2009 Parity IVF/ICSI (S) 12440 (S) 1097084 8
Tomic, 2011, Croatia [95] Hospital-based Retrospective 2006–2009 Ethnicity, age, gravidity, smoking habits, BMI, weight gain in pregnancy, site and time of delivery IVF/ICSI, Fresh embryo transfer (S) 283 (S) 283 7
Valenzuela-Alcaraz, 2013, Spain [96] Hospital-based Prospective N/A Age IVF/ICSI (S) 100 (S) 100 6
Valenzuela-Alcaraz, 2018, Spain [97] Hospital-based Prospective 2014–2016 No IVF/ICSI (M) 50 (M) 50 7
Vasario, 2012, Italy [98] Hospital-based Prospective 2004–2008 No IVF/ICSI (M) 84 (M) 139 6
Von Versen-Hoynck, 2019, US [99] Hospital-based Prospective 2011–2017 No IVF/ICSI, Fresh embryo transfer, Frozen embryo transfer (S) 367 (S)143 5
Watanabe, 2014, Japan [100] Hospital-based Retrospective 2009–2011 Closest propensity score (accounting for 27 maternal and paternal variables) IVF/ICSI (S) 474 (S) 474 9
Wennberg, 2016, Sweden, Denmark, Finland, Norway [101] Population-based Retrospective 1982–2007 Parity, year and month of birth IVF/ICSI, Fresh embryo transfer (S) 39919 (S) 260166 7
Wu, 2010, China
[102]
Hospital-based Retrospective 2006–2008 No IVF/ICSI (M) 204 (M) 255 4
Xu, 2005, China [103] Hospital-based Retrospective 2001–2003 No IVF/ICSI (M) 41 (M) 44 4
Yang, 2011, Korea [104] Hospital-based Retrospective 1995–2008 No IVF/ICSI (M) 67 (M) 143 7
Yang, 2014, China [105] Population-based Retrospective 2011 No IVF/ICSI (S) 825
(M) 314
(S) 109971
(M) 1473
6
Zadori, 2003, Hungary [106] Hospital-based Retrospective 1995–2002 Maternal age, parity, gravidity, previous obstetrics outcomes IVF/ICSI (S) 185
(M) 36
(S) 185
(M) 36
6
Zhang, 2015, China [107] Hospital-based Retrospective 2010–2014 No IVF/ICSI (M) 53 (M) 128 6
Zhu, 2016, China [108] Hospital-based Retrospective 2006–2014 Maternal age, birth year IVF/ICSI (S) 1659
(M) 982
(S) 5193
(M) 89
9