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Table 4 Multivariable logistic regression analysis on potential risk factors for pregnancy outcomes in GnRH-ant protocol (n = 918)

From: Effects of immediate versus delayed frozen embryo transfer in high responder patients undergoing freeze-all cycles

Potential risk factor variables Adjusted OR* (95% CI) P-value
Clinical pregnancy
 FET timing (Immediate FETa versus delayed FETb) 0.956 (0.721–1.267) NS
 Age (35–37 versus ≤34) 0.798 (0.502–1.269) NS
 Age (≥38 versus ≤34) 0.386 (0.210–0.708) P < 0.01
 BMI (< 18.5 versus 18.5–24.9) 0.781 (0.424–1.440) NS
 BMI (≥25 versus 18.5–24.9) 0.981 (0.731–1.315) NS
 Trigger type (GnRH-a trigger versus HCG trigger) 1.229 (0.891–1.695) NS
 Trigger type (Double trigger versus HCG trigger) 2.560 (1.143–5.737) P < 0.05
 Insemination method (ICSI versus IVF) 1.006 (0.696–1.453) NS
 Number of embryo transferred (2 versus 1) 1.726 (1.040–2.865) P < 0.05
 Embryo stage (blastocyst versus cleavage) 3.062 (1.871–5.011) P < 0.001
 Top or good quality embryo transfer (yes versus no) 0.984 (0.647–1.497) NS
 Tubal factor (yes versus no) 1.043 (0.745–1.461) NS
 Ovulatory disorder (yes versus no) 1.242 (0.909–1.695) NS
 Male factor (yes versus no) 1.012 (0.720–1.423) NS
 Unexplained factor (yes versus no) 1.268 (0.622–2.585) NS
Spontaneous abortion
 FET timing (Immediate FETa versus delayed FETb) 0.645 (0.430–0.966) P < 0.05
 Age (35–37 versus ≤34) 1.202 (0.620–2.329) NS
 Age (≥38 versus ≤34) 1.511 (0.696–3.280) NS
 BMI (< 18.5 versus 18.5–24.9) 0.716 (0.245–2.095) NS
 BMI (≥25 versus 18.5–24.9) 1.400 (0.934–2.100) NS
 Trigger type (GnRH-a trigger versus HCG trigger) 0.907 (0.570–1.445) NS
 Trigger type (Double trigger versus HCG trigger) 1.408 (0.613–3.232) NS
 Insemination method (ICSI versus IVF) 1.274 (0.756–2.144) NS
 Number of embryo transferred (2 versus 1) 1.036 (0.553–1.943) NS
 Embryo stage (blastocyst versus cleavage) 1.537 (0.830–2.845) NS
 Top or good quality embryo transfer (yes versus no) 0.971 (0.538–1.753) NS
 Tubal factor (yes versus no) 0.847 (0.550–1.389) NS
 Ovulatory disorder (yes versus no) 1.583 (1.017–2.465) P < 0.05
 Male factor (yes versus no) 0.793 (0.483–1.304) NS
 Unexplained factor (yes versus no) 0.978 (0.353–2.710) NS
Live birth
 FET timing (Immediate FETa versus delayed FETb) 1.220 (0.925–1.608) NS
 Age (35–37 versus ≤34) 0.761 (0.479–1.210) NS
 Age (≥38 versus ≤34) 0.249 (0.121–0.514) P < 0.001
 BMI (< 18.5 versus 18.5–24.9) 0.883 (0.484–1.609) NS
 BMI (≥25 versus 18.5–24.9) 0.798 (0.599–1.063) NS
 Trigger type (GnRH-a trigger versus HCG trigger) 1.250 (0.916–1.707) NS
 Trigger type (Double trigger versus HCG trigger) 1.867 (0.951–3.664) NS
 Insemination method (ICSI versus IVF) 0.939(0.655–1.347) NS
 Number of embryo transferred (2 versus 1) 1.637 (1.027–2.610) P < 0.05
 Embryo stage (blastocyst versus cleavage) 2.409 (1.533–3.785) P < 0.001
 Top or good quality embryo transfer (yes versus no) 1.052 (0.701–1.580) NS
 Tubal factor (yes versus no) 1.144 (0.825–1.588) NS
 Ovulatory disorder (yes versus no) 0.994 (0.734–1.345) NS
 Male factor (yes versus no) 1.154 (0.827–1.611) NS
 Unexplained factor (yes versus no) 1.232 (0.619–2.450) NS
  1. Abbreviations: BMI, body mass index; FET, frozen embryo transfer; GnRH-a, gonadotrophin-releasing hormone agonist; GnRH-ant, gonadotrophin-releasing hormone antagonist; IVF, in vitro fertilization; ICSI, intracytoplasmic sperm injection; OR, odds ratio; CI, confidence interval; NS, not significant
  2. aImmediate FET and bdelayed FET means FET took place either within the first menstrual cycle following oocyte retrieval or afterwards. *Using the multivariable logistic regression and adjusting for maternal age, BMI, insemination method, trigger type, number of embryo transferred, embryo stage, top or good quality embryo transfer, and cause of infertility