Skip to main content

Table 1 Baseline characteristics of immediate and delayed FET groups in the entire and propensity score-matched cohorts

From: Effects of immediate versus delayed frozen embryo transfer in high responder patients undergoing freeze-all cycles

Potential risk factors

Entire cohort

(n = 2128)

P-value

Propensity score-matched cohort*

(n = 1366)

P-value

Immediate FETa

Delayed FETb

Immediate FETa

Delayed FETb

(n = 1130)

(n = 998)

 

(n = 683)

(n = 683)

 

Maternal age (years)

  

0.455

  

1.000

  ≤ 34

976 (86.4)

851 (85.3)

 

622 (91.1)

622 (91.1)

 

 35–37

114 (10.1)

101 (10.1)

 

48 (7.0)

48 (7.0)

 

  ≥ 38

40 (3.5)

46 (4.6)

 

13 (1.9)

13 (1.9)

 

BMI (kg/m2)

  

0.431

  

1.000

  < 18.5

70 (6.2)

58 (5.8)

 

465 (68.1)

465 (68.1)

 

 18.5–24.9

750 (66.4)

641 (64.2)

 

22 (3.2)

22 (3.2)

 

  ≥ 25

310 (27.4)

299 (30.0)

 

196 (28.7)

196 (28.7)

 

Insemination method

  

0.056

  

1.000

 IVF

814 (72.0)

681 (68.2)

 

490 (71.7)

490 (71.7)

 

 ICSI

316 (28.0)

317 (31.8)

193 (28.3)

193 (28.3)

COH protocol

  

0.000

  

1.000

 GnRH-ant protocol

485 (42.9)

433 (43.4)

0.273#

284 (41.6)

284 (41.6)

0.651#

  HCG trigger

330 (68.0)

306 (70.7)

 

199 (70.1)

199 (70.1)

 

  GnRH-a trigger

137 (28.2)

105 (24.2)

79 (27.8)

79 (27.8)

  Double trigger

18 (3.7)

22 (5.1)

6 (2.1)

6 (2.1)

 Short acting GnRH-a protocol

566 (50.1)

434 (43.5)

 

335 (49.0)

335 (49.0)

 

Long acting GnRH-a protocol

79 (7.0)

131 (13.1)

 

64 (9.4)

64 (9.4)

 

Number of embryo transfer

  

0.000

  

1.000

 1

265 (23.5)

416 (41.7)

 

208 (30.5)

208 (30.5)

 

 2

865 (76.5)

582 (58.3)

475 (69.5)

475 (69.5)

Embryo stage

  

0.000

  

1.000

 Cleavage stage

711 (62.9)

499 (50.0)

 

418 (61.2)

418 (61.2)

 

 Blastocyst stage

419 (37.1)

499 (50.0)

265 (38.8)

265 (38.8)

Top or good quality embryo transfer

947 (83.3)

838 (84.0)

0.919

584 (85.5)

573 (83.9)

0.408

Cause of infertility

 Tubal factor

720 (63.7)

630 (63.1)

0.778

456 (66.8)

456 (66.8)

1.000

 Ovulatory disorder

304 (26.9)

257 (25.8)

0.548

167 (24.5)

167 (24.5)

1.000

 Male factor

452 (40.0)

420 (42.1)

0.329

273 (40.0)

273 (40.0)

1.000

 Unexplained factor

48 (4.2)

46 (4.6)

0.686

16 (2.3)

16 (2.3)

1.000

Multiple pregnancies

216 (19.1)

137 (13.7)

0.001

106 (15.5)

112 (16.4)

0.658

  1. Abbreviations: BMI, body mass index; COH, controlled ovarian hyperstimulation; FET, frozen embryo transfer; GnRH-a, gonadotrophin-releasing hormone agonist; GnRH-ant, gonadotrophin-releasing hormone antagonist; HRT, hormone replacement therapy; IVF, in vitro fertilization; ICSI, intracytoplasmic sperm injection. Data are presented as number (%)
  2. aImmediate FET and bDelayed FET means FET took place either within the first menstrual cycle following oocyte retrieval or afterwards
  3. *The predictors of propensity score matching were maternal age, BMI, insemination method, COH protocol, number of embryo transferred, embryo stage, top or good embryo transfer, and cause of infertility. The match tolerance was set to 0.000001. Categorical variables were compared with χ2 test. #P value of differences of different trigger drugs in GnRH-ant protocol