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Table 8 Sensitivity and Specificity of single or multiple indications for fetal pathogenic CNV

From: Investigation on combined copy number variation sequencing and cytogenetic karyotyping for prenatal diagnosis

   CNV Total McNemar’s χ 2 P value Sensitivity Specificity
   1 0
Positive for single indication 1 746 3315 4061 3286.1 <  0.001 0.99 (0.98, 0.99) 0.10 (0.09, 0.11)
0 9 356 365
Total   755 3671 4426
Positive for two indications 1 746 3315 4061 546.15 <  0.001 0.69 (0.65, 0.72) 0.70 (0.69, 0.72)
0 9 356 365
Total   755 3671 4426
Positive for three indications 1 180 88 268 356.25 <  0.001 0.24 (0.21, 0.27) 0.98 (0.97, 0.98)
0 575 3583 4158
Total   755 3671 4426
Positive for four indications 1 15 1 16 751.01 <  0.001 0.02 (0.01, 0.03) 1.00 (1.00, 1.00)
0 740 3670 4410
Total   755 3671 4426