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Table 1 Clinical profile of women with severe postpartum hemorrhage versus controls

From: Prevalence and risk factors of severe postpartum hemorrhage: a retrospective cohort study

 

SPPH(n = 506)

Controls (n = 32,828)

OR

95%CI

P

Maternal age (y)

  < 18

1 (0.20%)

20 (0.06%)

3.99

0.53–29.84

0.636

 18–34.9

318 (62.85%)

25,389 (77.34%)

Ref.

  

 35–39.9

149 (29.45%)

5883 (17.92%)

2.02

1.66–2.46

< 0.001

  ≥ 40

38 (7.51%)

1536 (4.68%)

1.98

1.41–2.78

< 0.001

Parity

 0

138 (27.27%)

17,913 (54.57%)

Ref.

  

 1–2

355 (70.16%)

14,698 (44.77%)

3.14

2.57–3.82

< 0.001

  ≥ 3

13 (2.57%)

217 (0.66%)

7.78

4.34–13.95

< 0.001

Previous cesarean deliverya

302 (81.84%)

6323 (42.34%)

6.14

4.70–8.01

< 0.001

BMI (kg/m2)

  < 18.5

41 (8.10%)

3239 (9.87%)

0.83

0.60–1.14

0.250

 18.5–24.9

354 (69.96%)

23,107 (70.39%)

Ref.

  

 25–29.9

91 (17.98%)

5531 (16.85%)

1.07

0.85–1.36

0.547

  ≥ 30

20 (3.95%)

951 (2.90%)

1.37

0.87–2.16

0.172

History of PPHb

20 (5.42%)

161 (1.08%)

5.26

3.27–8.47

< 0.001

Chronic hypertension

0 (0.00%)

79 (0.24%)

–

–

0.519

PGDM

0 (0.00%)

248 (0.76%)

–

–

0.089

Cardiac disease

8 (1.58%)

354 (1.08%)

1.47

0.73–2.99

0.282

IVF

84 (16.60%)

4283 (13.05%)

1.33

1.05–1.68

0.019

Irregular prenatal examination

282 (55.73%)

15,524 (47.29%)

1.40

1.18–1.68

< 0.001

Twins

34 (6.72%)

2186 (6.66%)

1.01

0.71–1.43

0.957

Hypertensive disorders of pregnancy

 Gestational hypertension

15 (2.96%)

706 (2.15%)

1.40

0.83–2.36

0.203

 Preeclampsia

26 (5.14%)

1422 (4.33%)

1.21

0.81–1.80

0.356

 Eclampsia

0 (0.00%)

18 (0.05%)

–

–

0.999

 HELLP syndrome

2 (0.40%)

68 (0.21%)

1.91

0.47–7.82

0.669

 GDM

105 (20.75%)

5369 (16.35%)

1.34

1.08–1.66

0.008

 Fibroids

5 (0.99%)

172 (0.52%)

1.90

0.78–4.63

0.264

 Anemia

158 (31.23%)

2954 (9.00%)

4.59

3.79–5.56

< 0.001

 Thrombocytopenia

6 (1.13%)

317 (0.97%)

1.23

0.55–2.77

0.785

 Blood coagulation disorder

2 (0.40%)

43 (0.13%)

3.03

0.73–12.52

0.319

 Stillbirth

7 (1.38%)

132 (0.40%)

3.48

1.62–7.47

0.002

 Induction of labor

22 (4.35%)

3045 (9.28%)

0.45

0.29–0.68

< 0.001

 Prolonged labor

18 (3.56%)

583 (1.78%)

2.04

1.27–3.29

0.003

 Precipitate labor

1 (0.20%)

219 (0.67%)

0.30

0.04–2.11

0.309

Mode of delivery

 Vaginal delivery

370 (73.12%)

27,780 (84.62%)

Ref.

  

 Cesarean section

136 (26.88%)

5408 (16.47%)

2.02

1.66–2.47

< 0.001

Placenta previa

311 (61.46%)

1392 (4.24%)

36.02

29.88–43.42

< 0.001

Placental abruption

11 (2.17%)

337 (1.03%)

2.14

1.17–3.93

0.014

PAS

283 (55.93%)

1076 (3.28%)

37.45

31.10–45.09

< 0.001

Macrosomia

41 (8.10%)

2553 (7.78%)

1.05

0.76–1.44

0.79

  1. Data presented as n (%), odds ratio (OR) and 95% confidence intervals (CI)
  2. Previous cesarean deliverya: nulliparous women were removed from the denominator, 302/369 (81.84%) in SPPH, and 6323/14934 (42.34%) in controls
  3. History of PPHb: nulliparous women were removed from the denominator, 20/369 (5.42%) in SPPH, and 161/14934 (1.08%) in controls
  4. SPPH severe postpartum hemorrhage, BMI body mass index, PGDM pre-gestational diabetes mellitus, IVF in vitro fertilization, HELLP syndrome, hemolysis elevated liver enzymes, low platelet count, GDM gestational diabetes mellitus, PAS placenta accrete spectrum