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Table 3 Maternal and neonatal delivery outcomes of normoglycaemic women, and those classified as GDM

From: Antenatal management and maternal/fetal outcomes associated with hyperglycaemia in pregnancy (HIP) in Uganda; a prospective cohort study

 

Normoglycaemic n = 2641

(Proportion) %

HIP

n = 276

Risk Ratio (95% CI)

p-value

  
     

GDM

n = 276

DIP

n = 39

MATERNAL OUTCOMES

 Maternal Death

(0/2917) 0.0

(1/276) 0.003

–

–

(1/237) 0.004

(0/39) 0.0

 Antepartum complications

  Hypertensive disorder

(101/2641) 3.8

(27/276) 9.8

2.56 (1.70–3.84)

< 0.001

(19/237) 8.0

(8/39) 20.5

  Poly/oligohydramnios

(34/2641) 1.3

(7/276) 2.5

1.97 (0.88–4.40)

0.09

(7/237) 3.0

(0/39) 0.0

 Caesarean delivery

(743/2591) 28.7

(104/271) 38.4

1.34 (1.14–1.57)

< 0.001

(93/234) 39.7

(11/37) 29.7

 Maternal delivery complications

  Prolonged labour

(168/2641) 6.4

(16/276) 5.8

0.91 (0.55–1.50)

0.71

(15/237) 6.3

(1/39) 2.6

  Ruptured uterus

(5/2641) 0.2

(0/276) 0.0

–

–

(1/237) 0.0

(0/39) 0.0

  Shoulder dystocia

(3/2641) 0.1

(0/276) 0.0

–

–

(0/237) 0.0

(0/39) 0.0

NEONATAL OUTCOMES

 Perinatal mortality

(74/2641) 2.8

(7/276) 2.5

0.91 (0.42–1.95)

0.80

(5/237) 2.1

(2/39) 5.1

  Stillbirth (> 24 weeks)

(45/2641) 1.7

(5/276) 1.8

1.06 (0.43–2.66)

0.90

(3/237) 1.3

(2/39) 5.1

  Neonatal death (< 28 days)

(29/2567) 1.1

(2/271) 0.7

0.65 (0.16–2.72)

0.56

(2/233) 0.9

(0/37) 0.0

 Mean birthweight (g)

3268.1 ± 551

3327.5 ± 535

–

0.10

3315.1 ± 512

3403.3 ± 660

  LGA (>90th centile)

(514/2493) 20.6

(68/264) 25.8

1.30 (1.00–1.68)

0.05

(56/227) 24.7

(12/37) 32.4

  Macrosomia (> 4 kg)

(212/2503) 8.5

(30/264) 11.4

1.34 (0.94–1.92)

0.11

(22/227) 9.7

(8/37) 21.6

  SGA (<10th centile)

(235/2493) 9.4

(21/264) 8.0

0.84 (0.55–1.29)

0.43

(20/227) 8.8

(1/37) 2.7

  Low birth weight (< 2.5 kg)

(211/2503) 8.4

(22/264) 8.3

0.99 (0.65–1.51)

0.96

(19/227) 8.4

(3/37) 8.1

 Mean GA at delivery (weeks)

38.7 ± 1.8

38.5 ± 1.7

–

0.23

38.6 ± 1.5

37.9 ± 2.3

  Very Preterm birth (<34w)

(53/2596) 2.0

(6/271) 2.2

1.08 (0.47–2.50)

0.85

(3/234) 1.3

(3/37) 8.1

  Preterm birth (< 37 weeks)

(328/2596) 12.6

(38/271) 14.0

1.11 (0.81–1.52)

0.51

(29/234) 12.4

(9/37) 24.3

 Neonatal admission

(289/2577) 11.2

(44/269) 16.4

1.45 (1.09–1.95)

0.01

(33/232) 14.2

(11/37) 29.7

  Median length stay, IQR (days)

2 1–4

2 1–3

–

 

2 1–3

2.5 2–4

 Umbilical cord c-peptide n = 445

  Median, IQR (mcg/L)

0.53 0.17–0.89

0.48 0.24–1.03

–

–

0.48 0.28–0.91

0.64 0.19–1.50

 Neonatal complications

  Hypoglycaemia

(9/2588) 0.4

(4/263) 1.5

4.37 (1.36–14.1)

< 0.01

(4/227) 1.8

(0/36) 0.0

  Jaundice

(48/2612) 1.8

(2/271) 0.7

0.40 (0.10–1.64)

0.19

(1/232) 0.4

(1/39) 2.6

  1. LGA large for gestational age, SGA small for gestational age, GA gestational age, IQR interquartile range