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Table 3 Pregnancy-related complications of pregnancies carried to delivery following FET with different endometrial preparation protocols

From: Perinatal outcomes of neonates born from different endometrial preparation protocols after frozen embryo transfer: a retrospective cohort study

 

Singleton delivery

Multiple delivery

NC (N = 1491)

OS (N = 272)

HRT (N = 1234)

aOR (95%CI)a

aOR (95%CI)a

NC (N = 430)

OS (N = 88)

HRT (N = 349)

aOR (95%CI)a

aOR (95%CI)a

No. (%)

No. (%)

No. (%)

OS vs.NC

HRT vs. NC

No. (%)

No. (%)

No. (%)

OS vs.NC

HRT vs. NC

Gestational diabetes mellitus

 No

1351 (90.61)

237 (87.13)

1110 (89.95)

Reference

Reference

383 (89.07)

75 (85.23)

323 (92.82)

Reference

Reference

 Yes

140 (9.39)

35 (12.87)

124 (10.05)

1.44 (0.97–2.16)

1.07 (0.82–1.40)

47 (10.93)

13 (14.77)

25 (7.18)

1.38 (0.70–2.71)

0.63 (0.37–1.06)

Hypertensive disorder

 No

1301 (87.26)

216 (79.41)

998 (80.88)

Reference

Reference

361 (83.95)

66 (75.00)

243 (69.63)

Reference

Reference

 Gestational hypertension

91 (6.10)

20 (7.35)

90 (7.29)

1.34 (0.80–2.26)

1.31 (0.96–1.79)

30 (6.98)

7 (7.95)

41 (11.75)

1.38 (0.58–3.32)

1.99 (1.19–3.32)

 Preeclampsia

99 (6.64)

36 (13.24)

146 (11.83)

2.24 (1.48–3.38)

1.88 (1.43–2.48)

39 (9.07)

19 (21.59)

65 (18.62)

2.91 (1.56–5.41)

2.43 (1.56–3.78)

Intrahepatic cholestasis of pregnancy

 No

1433 (96.11)

253 (93.01)

1152 (93.35)

Reference

Reference

414 (96.28)

80 (90.91)

319 (91.40)

Reference

Reference

 Yes

58 (3.89)

19 (6.99)

82 (6.65)

2.09 (1.21–3.59)

1.85 (1.29–2.63)

16 (3.72)

8 (9.09)

30 (8.60)

2.62 (1.07–6.38)

2.37 (1.25–4.48)

Meconium staining of the amniotic fluid

 No

1274 (85.45)

225 (82.72)

1012 (82.01)

Reference

Reference

372 (86.51)

76 (86.36)

299 (85.67)

Reference

Reference

 Yes

217 (14.55)

47 (17.28)

222 (17.99)

1.27 (0.90–1.80)

1.31 (1.06–1.61)

58 (13.49)

12 (13.64)

50 (14.33)

1.07 (0.54–2.11)

1.07 (0.70–1.63)

Preterm birth

 No

1310 (87.86)

251 (92.28)

1064 (86.22)

Reference

Reference

210 (48.84)

38 (43.18)

150 (42.98)

Reference

Reference

 Preterm

181 (12.14)

21 (7.72)

170 (13.78)

0.63 (0.39–1.02)

1.21 (0.95–1.53)

220 (51.16)

50 (56.82)

199 (57.02)

1.32 (0.82–2.11)

1.27 (0.95–1.70)

Mode of delivery

 Vaginal

665 (44.60)

109 (40.07)

480 (38.90)

Reference

Reference

17 (3.95)

4 (4.55)

13 (3.72)

Reference

Reference

 Cesarean section

826 (55.40)

163 (59.93)

754 (61.10)

1.15 (0.88–1.50)

1.24 (0.96–1.45)

413 (96.05)

84 (95.45)

336 (96.28)

0.93 (0.30–2.88)

1.15 (0.54–2.47)

  1. FET frozen embryo transfer, NC natural cycles, OS ovarian stimulation, HRT hormonal replacement therapy, aOR adjusted odds ratio, CI confidence interval
  2. aaOR was adjusted for age at oocyte retrieval, age at embryo transfer, BMI and cause of infertility