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Table 3 Subgroup and additive interaction analyses of physical activity and sleep duration for CD

From: Physical activity and sleep duration during pregnancy have interactive effects on caesarean delivery: a population-based cohort study in Tianjin, China

Variables

OR (95% CI)

Model 1

Model 2

Model 3

Subgroup analyses

 Among sleep time < 9 h/day

     Low V.S Moderate-to-high PA

1.04 (0.94–1.16)

1.04 (0.92–1.17)

1.03 (0.91–1.16)

 Among sleep time ≥ 9 h/day

     Low V.S Moderate-to-high PA

1.16 (1.06–1.28)

1.20 (1.08–1.34)

1.22 (1.09–1.36)

 Among low PA

     ≥9 h/day V.S < 9 h/day sleep time

1.15 (1.04–1.27)

1.21 (1.09–1.35)

1.22 (1.10–1.37)

 Among moderate-to-high PA

     ≥9 h/day V.S < 9 h/day sleep time

1.03 (0.92–1.14)

1.03 (0.92–1.16)

1.02 (0.90–1.15)

Additive interaction models

     Moderate-to-high PA and sleep time < 9 h/day

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

     Low PA and sleep time < 9 h/day

1.04 (0.94–1.16)

1.04 (0.92–1.16)

1.03 (0.91–1.16)

     Moderate-to-high PA and sleep time ≥ 9/day

1.03 (0.92–1.14)

1.04 (0.93–1.17)

1.03 (0.92–1.16)

     Low PA and sleep time ≥ 9 h/day

1.20 (1.08–1.33)

1.25 (1.12–1.41)

1.25 (1.12–1.41)

Additive interaction indications

     RERI

0.13 (−0.02–0.28)

0.17 (0.01–0.34)

0.20 (0.03–0.36)

     AP

0.11 (− 0.02–0.23)

0.14 (0.01–0.27)

0.16 (0.02–0.29)

     S

2.85 (0.24–33.50)

3.20 (0.30–34.42)

4.40 (0.15–130.67)

  1. Abbreviations: CD caesarean delivery; PA physical activity; RERE relative excess risk due to interaction; AP attributable proportion due to interaction and S synergy index. RERI> 0, AP > 0, or S > 1 suggest significant additive interaction; OR odds ratio; CI confidence interval
  2. Model 1: Univariable analyses
  3. Model 2: Multivariable analyses, adjusted for age, body mass index, weight gain from registration to glucose challenge test, gestational age at delivery, habitual smokers before and during pregnancy, alcohol drinkers before and during pregnancy, family history of diabetes in first-degree relatives, parity≥1, Han nationality, systolic blood pressure at registration for pregnancy, birth weight, neonatal height
  4. Model 3: Further adjusted for gestational diabetes, in addition to the variables listed in model 2