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Table 5 Performance of the number of weeks between the placental perfusion measurement and delivery in screening for unexplained stillbirths under regular and assumed conditions

From: Abnormal placental perfusion and the risk of stillbirth: a hospital-based retrospective cohort study

Stratification Area under the curve (95% CI) Initiation time (weeks) Regular condition Assumed condition a
Criterion value (weeks) Sensitivity (% (95% CI)) Specificity (% (95% CI)) Criterion value (weeks) Sensitivity (% (95% CI)) Specificity (% (95% CI))
Placental perfusion
 Normal group 0.948 (0.945–0.951) ≥ 3 ≤ 15.0 90.5 (69.6 ~ 98.8) 83.4 (83.0–83.9) ≤ 11.8 66.7 (43.0 ~ 85.4) 98.8 (98.7–99.0)
 APP group 0.867 (0.855–0.878) ≥ 5 ≤ 14.6 85.7 (57.2 ~ 98.2) 84.4 (83.1–85.5) ≤ 14.0 78.6 (49.2 ~ 95.3) 89.4 (88.3–90.4)
Sex
 Male 0.972 (0.969–0.974) ≥ 3 ≤ 14.6 100 (76.8–100) 89.03 (88.5–89.5) ≤ 8.3 50 (23.0–77.0) 99.7 (99.6–99.7)
 Female 0.895 (0.890–0.900) ≥ 4 ≤ 15.0 80.9 (58.1–94.6) 83.66 (83.1–84.2) ≤ 11.9 61.9 (38.4–81.9) 98.7 (98.5–98.9)
Combination
 Normal and male 0.985 (0.983–0.987) ≥ 3 ≤ 14.1 100 (66.4–100) 93.3(92.9–93.7) ≤ 8.3 66.7 (29.9–92.5) 99.7 (99.6–99.8)
 Normal and female 0.924 (0.920–0.929) ≥ 4 ≤ 15.4 91.7 (61.5–99.8) 76.41 (75.7–77.1) ≤ 11.3 58.3 (27.7–84.8) 99.2 (99.0–99.3)
 APP and male 0.920 (0.906–0.931) ≥ 5.1 ≤ 14.6 100 (47.8–100) 84.0 (82.2–85.6) ≤ 14.6 100 (47.8–100) 84.0 (82.2–85.6)
 APP and female 0.839 (0.820–0.857) ≥ 5 ≤ 14.0 77.8 (40.0–97.2) 89.5 (87.9–90.9) ≤ 11.9 66.7 (29.9–92.5) 96.8 (95.8–97.6)
  1. a Assumed condition: the cost of a false negative decision was 100 times that of a false positive decision (cost of false positive decision was 1, cost of false negative decision was 100, and the costs of both a true positive and negative decision were 0), and the rate of unexplained stillbirths in the sample reflects the real prevalence of stillbirth in the population
  2. P < 0.05 compared with the normal and male groups