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Table 3 Variant in placental perfusion insufficiency and odds ratio of stillbirth

From: Abnormal placental perfusion and the risk of stillbirth: a hospital-based retrospective cohort study

Variant of placental perfusion insufficiency All (56 cases) Unexplained (48 cases)
  No. of infants No. of cases Prevalence (‰) (95% CI) Adjusted odds ratio (95% CI) a P value No. of infants No. of cases Prevalence (‰) (95% CI) Adjusted odds ratio (95% CI) a P value
Right uterine artery
 PI Normal (≤P95) 29,709 31 1.0 (0.7–1.4) 1.0   29,704 26 0.9 (0.5–1.2) 1.0  
High (>P95) 1560 9 5.8 (2.0–9.5) 3.9 (1.8–8.6) 0.001 1560 9 5.8 (2.0–9.5) 4.8 (2.1–10.7) < 0.001
NA 10,371 16 1.5 (0.8–2.3) 1.4 (0.8–2.6) 0.27 10,368 13 1.3 (0.6–1.9) 1.3 (0.7–2.6) 0.39
 RI Normal (≤P95) 29,881 33 1.1 (0.7–1.5) 1.0   29,876 28 0.9 (0.6–1.3) 1.0  
High (>P95) 1388 7 5.0 (1.3–8.8) 3.2 (1.4–7.5) 0.008 1388 7 5.0 (1.3–8.8) 3.8 (1.6–9.1) 0.003
NA 10,371 16 1.5 (0.8–2.3) 1.3 (0.7–2.4) 0.35 10,368 13 1.3 (0.6–1.9) 1.3 (0.6–2.5) 0.50
 EDN No 31,011 39 1.3 (0.9–1.7) 1.0   31,006 34 1.1 (0.7–1.5) 1.0  
Yes 275 1 3.6 (0.0–10.8) 1.5 (0.2–11.5) 0.70 275 1 3.6 (0.0–10.8) 1.8 (0.2–13.7) 0.58
NA 10,354 16 1.5 (0.8–2.3) 1.2 (0.7–2.1) 0.58 10,351 13 1.3 (0.6–1.9) 1.1 (0.6–2.1) 0.81
Left uterine artery
 PI Normal (≤P95) 29,660 31 1.0 (0.7–1.4) 1.0   29,656 27 0.9 (0.6–1.3) 1.0  
High (>P95) 1566 9 5.7 (2.0–9.5) 4.0 (1.8–8.7) 0.001 1565 8 5.1 (1.6–8.6) 4.1 (1.8–9.4) 0.001
NA 10,414 16 1.5 (0.8–2.3) 1.4 (0.8–2.6) 0.28 10,411 13 1.2 (0.6–1.9) 1.3 (0.7–2.5) 0.47
 RI Normal (≤P95) 19,759 30 1.0 (0.6–1.4) 1.0   29,755 26 0.9 (0.5–1.2) 1.0  
High (>P95) 1467 10 6.8 (2.6–11.0) 5.1 (2.4–10.8) < 0.001 1466 9 6.1 (2.1–10.1) 5.3 (2.4–11.8) < 0.001
NA 10,414 16 1.5 (0.8–2.3) 1.5 (0.8–2.7) 0.23 10,411 13 1.2 (0.6–1.9) 1.3 (0.7–2.6) 0.39
 EDN No 30,891 40 1.3 (0.9–1.7) 1.0   30,886 35 1.1 (0.8–1.5) 1.0  
Yes 393 0   393 0  
NA 10,356 16 1.5 (0.8–2.3) 1.1 (0.6–2.1) 0.66 10,353 13 1.3 (0.6–1.9) 1.0 (0.5–2.0) 0.9
No. of insufficiency markers
 0 27,724 25 0.9 (0.5–1.3) 1.0   27,720 21 0.8 (0.4–1.1) 1.0  
 1 1263 3 2.4 (0.0–5.1) 2.4 (0.7–8.1) 0.15 1263 3 2.4 (0.0–5.1) 2.9 (0.9–9.9) 0.083
 2 1626 7 4.3 (1.1–7.5) 4.1 (1.8–9.7) 0.001 1625 6 3.7 (0.7–6.6) 4.2 (1.7–10.6) 0.002
 3 and above 596 5 8.4 (1.0–15.7) 5.3 (1.9–15.2) 0.002 596 5 8.4 (1.0–15.7) 6.5 (2.2–19.0) 0.001
 NA 10,431 16 1.5 (0.8–2.3) 1.6 (0.9–3.0) 0.14 10,428 13 1.2 (0.6–1.9) 1.5 (0.8–3.1) 0.23
  1. Abbreviations: PI Pulsatility index, RI Resistance index, EDN Early diastolic notching
  2. a Adjusted for maternal age at delivery (< 25, 25–34, or ≥ 35), residence (local or nonlocal), parity (nulliparous or pluriparous), gestational diabetes mellitus (yes or no), assisted conception (yes or no), preeclampsia (yes or no) and sex (male or female)