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Table 5 Neonatal outcomes of the AFLP and HELLP syndrome groups

From: Comparison of maternal and neonatal outcomes between acute fatty liver of pregnancy and hemolysis, elevated liver enzymes and low platelets syndrome: a retrospective cohort study

 

AFLP versus HELLP syndrome

AFLP versus complete HELLP syndrome

 

AFLP

(n = 27)

HELLP syndrome

(n = 84)

P

Pa

Adjusted B or OR

(95 % CI)

AFLP

(n = 27)

Complete HELLP syndrome (n = 18)

P

Pa

Adjusted B or OR

(95 % CI)

Birth age (weeks)b

34.6 (3.4)

(33, 36)

33.9 (6.9)

(32, 34)

0.137

  

34.6 (3.4)

(33, 36)

34 (4)

(32, 36)

0.449

  

Birth weight (g)c

2235.5 ± 591.7

(1996.5, 2474.5)

1686.1 ± 735.1

(1518.1, 1854)

0.001*

0.006*

590.5

(177.7, 1003.4)

2235.5 ± 591.7

(1996.5, 2474.5)

1784.0 ± 583.17

(1473.3, 2094.7)

0.020*

0.015*

606.97

(126.55, 1087.38)

Apgar score (1 min)b

8 (5)

7 (3)

0.540

  

8 (5)

6.5 (2)

0.378

  

Apgar score (5 min)b

9 (3)

9 (1)

0.512

  

9 (3)

8.5 (1)

0.328

  

Maled

17/27 (63)

45/84 (53)

0.393

  

17/27 (63)

12/18 (66.7)

0.799

  

SGAd

9/27 (33.3)

48/84 (57.1)

0.031*

0.049*

0.32

(0.10, 0.99)

9/27 (33.3)

12/18 (66.7)

0.028*

0.029*

0.15

(0.03, 0.82)

Stillbirthd

3/27 (11.1)

5/84 (6)

0.400

  

3/27 (11.1)

0/18 (0)

0.143

  

Live birth complication

          

ICHd

0/24 (0)

3/79 (3.8)

> 0.99

  

0/24 (0)

0/18 (0)

NA

  

RDSd

2/24 (8.3)

31/79 (39.2)

0.004*

0.012*

0.11

(0.02, 0.61)

2/24 (8.3)

7/18 (38.9)

0.025*

0.042*

0.14

(0.02, 0.93)

TTNd

11/24 (45.8)

31/79 (39.2)

0.565

  

11/24 (45.8)

11/18 (61.1)

0.327

  

PPHNd

0/24 (0)

2/79 (2.5)

> 0.99

  

0/24 (0)

0/18 (0)

NA

  

Sepsisd

3/24 (12.5)

27/79 (34.2)

0.041*

0.024*

0.17

(0.04, 0.79)

3/24 (12.5)

8/18 (44.4)

0.033*

0.033*

0.12

(0.02, 0.85)

NICU admissiond

10/24 (41.7)

43/79 (54.4)

0.273

  

10/24 (41.7)

11/18 (61.1)

0.212

  

Neonatal mortalityd

0/24 (0)

6/79 (7.6)

0.332

  

0/24 (0)

0/18 (0)

NA

  
  1. AFLP acute fatty liver of pregnancy; HELLP hemolysis, elevated liver enzymes and low platelets; OR odds ratio; CI confidence interval; SGA small for gestational age; ICH intracranial hemorrhage; NA non-applicable; RDS respiratory distress syndrome; TTN transient tachypnea of the newborn; PPHN persistent pulmonary hypertension of the newborn; NICU neonatal intensive care unit
  2. aP adjusted by maternal body mass index and twin pregnancy
  3. bMann-Whitney U test, results are presented as median (interquartile range), (95 % confidence interval)
  4. cStudent’s t test, results are presented as mean ± standard deviation, (95 % confidence interval)
  5. dChi-square or Fisher’s exact test, results are presented as number (percentage)
  6. *P < 0.05 was considered to be statistically significant