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Table 3 Maternal laboratory data of the AFLP and HELLP syndrome groups

From: Comparison of maternal and neonatal outcomes between acute fatty liver of pregnancy and hemolysis, elevated liver enzymes and low platelets syndrome: a retrospective cohort study

 

AFLP versus HELLP syndrome

AFLP versus complete HELLP syndrome

 

AFLP

(n = 21)

HELLP syndrome

(n = 80)

P

Pa

Adjusted B

(95 % CI)

AFLP

(n = 21)

Complete HELLP syndrome (n = 18)

P

Pa

Adjusted B (95 % CI)

Hemoglobin (g/dL)b

13.4 ± 1.9

(12.5, 14.2)

12.4 ± 2.2

(11.9, 12.9)

0.069

  

13.4 ± 1.9

(12.5, 14.2)

12.6 ± 2.5

(11.3, 13.8)

0.272

  

Leucocyte (106/mL)c

14.5 (10.8)

(9.9, 19.5)

11.8 (6.2)

(10.7, 12.8)

0.362

  

14.5 (10.8)

(9.9, 19.5)

12.7 (6.9)

(10.5, 17)

0.662

  

Platelet (103/µL)c

174 (147)

(130, 260)

89 (106.5)

(76, 105)

< 0.001*

< 0.001*

97.37

(50.06, 144.68)

174 (147)

(130, 260)

69.5 (41)

(54, 91)

< 0.001*

< 0.001*

135.57

(74.41, 196.74)

Glucose (mg/dL)c

85 (29)

(66, 95)

98.5 (2)

(95, 104)

< 0.001*

0.001*

-19.80

(-31.30, -8.30)

85 (29)

(66, 95)

97 (25)

(94, 108)

0.004*

0.004*

-24.10

(-39.94, -8.27)

Bilirubin (mg/dL)c

4.4 (7.5)

(2.4, 9.4)

0.9 (0.8)

(0.8, 1.1)

< 0.001*

< 0.001*

5.65

(3.35, 7.95)

4.4 (7.5)

(2.4, 9.4)

1.3 (1.5)

(0.9, 2.4)

0.001*

0.040*

4.54

(0.23, 8.84)

AST (IU/L)c

257 (335)

(153, 425)

124 (153)

(93, 158)

0.003*

0.109

119.23

(-27.21, 265.66)

257 (335)

(153, 425)

229 (375)

(141, 496)

> 0.99

  

ALT (IU/L)c

316 (389)

(146, 520)

135 (138.8)

(103, 165)

0.006*

0.074

162.14

(-16.28, 340.57)

316 (389)

(146, 520)

181.5 (370)

(94, 386)

0.345

  

Uric acid (mg/dL)c

8.3 (2.1)

(6.7, 9.7)

7.9 (1.4)

(7.1, 9.1)

0.681

  

8.3 (2.1)

(6.7, 9.7)

7.3 (2.3)

(5.3, 11.7)

0.339

  

Ammonia (µg/dL)b

79.9 ± 23.6

(67.3, 92.5)

66.0 ± 9.0

(56.5, 75.5)

0.154

  

79.9 ± 23.6

(67.3, 92.5)

67.5 ± 16.3

(56.3, 78.5)

0.488

  

Creatinine (mg/dL)c

1.8 (1.1)

(1.3, 2.4)

0.8 (0.5)

(0.8, 1.1)

< 0.001*

0.059

0.51

(-0.02, 1.03)

1.8 (1.1)

(1.3, 2.4)

0.9 (0.8)

(0.7, 1.4)

0.005*

0.026*

0.60

(0.08, 1.13)

LDH (IU/L)c

457 (281)

(282, 601)

489.5 (317.3)

(402, 479)

0.535

  

457 (281)

(282, 601)

765 (782)

(641, 1346)

< 0.001*

0.041*

-342.51

(-670.38, -14.64)

PT (s)c

14.1 (10)

(12.6, 19.9)

9.5 (1.3)

(9.3, 9.7)

< 0.001*

< 0.001*

8.17

(4.71, 11.63)

14.1 (10)

(12.6, 19.9)

9.6 (0.6)

(9.4, 9.8)

< 0.001*

0.024*

8.38

(1.19, 15.57)

aPTT (s)c

38.5 (19.3)

(32.5, 49.6)

27.9 (4.1)

(27.5, 28.7)

< 0.001*

< 0.001*

16.34

(8.07, 24.62)

38.5 (19.3)

(32.5, 49.6)

27.7 (3.1)

(25.8, 28.4)

0.001*

0.043*

17.86

(0.62, 35.10)

Fibrinogen (mg/dL)b

193 ± 114.7

(126.7, 259.2)

408.1 ± 153.5

(366.2, 450)

< 0.001*

< 0.001*

-234.34

(-341.11, -127.57)

193 ± 114.7

(126.7, 259.2)

335.6 ± 121.4

(242.2, 428.9)

0.010*

0.006*

-218.82

(-364.01, 73.63)

  1. AFLP acute fatty liver of pregnancy; HELLP hemolysis, elevated liver enzymes and low platelets; CI confidence interval; AST aspartate transaminase; ALT alanine aminotransferase; LDH lactate dehydrogenase; PT prothrombin time; aPTT activated partial thromboplastin time
  2. aP adjusted by BMI and twin pregnancy status
  3. bStudent’s t test, results are presented as mean ± standard deviation, (95 % confidence interval)
  4. cMann-Whitney U test, results are presented as median (interquartile range), (95 % confidence interval)
  5. *P < 0.05 was considered to be statistically significant