Maternal overweight but not paternal overweight before pregnancy is associated with shorter newborn telomere length: evidence from Guangxi Zhuang birth cohort in China

Table 3 Associations between parental pre-pregnancy BMI and newborn TL, stratified by newborn sex

Subgroup	Unadjusted		Model A		Model B
Subgroup	Percentage change (95% CI)	P-value	Percentage change (95% CI)	P-value	Percentage change (95% CI)	P-value
Male (n = 582)
Maternal BMI
NW	Ref		Ref		Ref
UW	0.69(− 5.38,7.15)	0.839	0.23(− 6.03,6.91)	0.934	0.46(− 5.81,7.15)	0.905
OW	−9.84(− 17.96, − 0.92)	0.033	−9.22(− 17.59,0.00)	0.048	−9.01(− 17.40,0.23)	0.054
Paternal BMI
HW	Ref		Ref		Ref
OW	2.33(−7.32,12.72)	0.655	2.57(− 7.10,12.98)	0.616	2.09(− 7.53,12.72)	0.686
Parents’ weight status combination
Both parents HW	Ref		Ref		Ref
OW father, HW mother	2.80(−7.10,13.76)	0.588	3.04(−6.89,14.02)	0.568	2.33(−7.74,13.24)	0.670
OW mother, HW father	−9.43(−17.78, −0.23)	0.047	−8.80(− 17.40,0.69)	0.071	− 8.80(− 17.59,0.69)	0.068
Both parents OW	− 14.10(− 39.19,21.34)	0.388	− 14.10(− 39.19,21.34)	0.388	−10.05(− 36.61,27.64)	0.550
Female (n = 500)
Maternal BMI
NW	Ref		Ref		Ref
UW	−0.23(−6.24,6.17)	0.915	0.00(−6.03,6.66)	0.972	0.46(−5.81,7.15)	0.899
OW	−5.16(−15.67,6.66)	0.366	−6.67(− 17.21,5.44)	0.267	− 6.46(− 17.01,5.68)	0.281
Paternal BMI
HW	Ref		Ref		Ref
OW	−0.46(−9.43,9.65)	0.932	−0.23(− 9.43,9.90)	0.965	0.23(− 9.01,10.15)	0.972
Parents’ weight status combination
Both parents HW	Ref		Ref		Ref
OW father, HW mother	−1.14(−10.67,9.14)	0.804	−1.37(− 10.67,9.14)	0.803	−0.92(− 10.26,9.65)	0.867
OW mother, HW father	−6.67(− 17.59,5.68)	0.280	−8.38(−19.46,4.23)	0.179	−8.38(−19.46,4.23)	0.187
Both parents OW	3.99(−23.62,41.91)	0.802	4.71(−23.26,43.22)	0.767	4.95(−23.26,43.55)	0.759

Abbreviation: BMI Body mass index, TL Telomere length, UW Underweight, NW Normal weight, HW Normal and underweight, OW Overweight
Models’ adjustments were according to Table 2

ISSN: 1471-2393