Maternal overweight but not paternal overweight before pregnancy is associated with shorter newborn telomere length: evidence from Guangxi Zhuang birth cohort in China

Table 2 Categorized analysis between parental pre-pregnancy BMI and newborn TL

All (n = 1082)	Unadjusted		Model A		Model B
All (n = 1082)	Percentage change (95% CI)	P-value	Percentage change (95% CI)	P-value	Percentage change (95% CI)	P-value
Maternal BMI
NW	Ref		Ref		Ref
UW	−0.23(−4.50,4.23)	0.937	0.23(−4.28,4.71)	0.958	0.23(−4.28,4.95)	0.929
OW	−7.96(−14.49, − 0.92)	0.029	−8.17(− 14.89, − 0.92)	0.026	− 7.96(− 14.49, − 0.69)	0.032
Paternal BMI
HW	Ref		Ref		Ref
OW	0.69(−6.03,7.65)	0.850	0.93(−5.59,8.14)	0.785	0.93(−5.59,8.14)	0.772
Parents’ weight status combination
Both parents HW	Ref		Ref		Ref
OW father, HW mother	0.46(−6.24,7.89)	0.892	0.69(−6.24,7.89)	0.869	0.69(−6.24,8.14)	0.866
OW mother, HW father	−8.17(−14.89, −0.92)	0.030	− 8.59(− 15.67, − 1.14)	0.024	−8.38(− 15.47, − 0.92)	0.028
Both parents OW	−4.50(−23.97,20.23)	0.698	−3.39(− 23.26,21.62)	0.768	−2.50(−22.55,22.74)	0.830

Abbreviation: BMI Body mass index, TL Telomere length, UW Underweight, NW Normal weight, HW Healthy weight (normal and underweight), OW Overweight
Model A: adjusted for parental age, newborn factors (sex, gestational age and birth weight)
Model B: Model A + maternal factors (residential place, gravidity, parity, drinking before pregnancy, passive smoking during pregnancy, pregnancy comorbidities or complications, and cesarean section)
Estimates are presented as a percentage change in average relative telomere length

ISSN: 1471-2393