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Table 1 The characteristics of the study group in the DNA methylation analysis by delivery mode

From: The impact of cesarean delivery on infant DNA methylation

 

DNA methylation chip analysis

DNA methylation validation analysis

VD (n = 30)

CDMR (n = 30)

p

VD (n = 40)

CDMR (n = 40)

p

Gestational age (weeks)

 

1.00

  

0.14

 37

2 (6.7)

1 (3.3)

 

2 (5.0)

1 (2.5)

 

 38

8 (26.7)

7 (23.3)

 

7 (17.5)

11 (27.5)

 

 39

14 (46.7)

15 (50.0)

 

12 (30.0)

18 (45.0)

 

  ≥ 40

6 (20.0)

7 (23.3)

 

19 (47.5)

10 (25.0)

 

Birthweight (grams)

3281 ± 287

3392 ± 262

0.12

3392 ± 295

3430 ± 295

0.57

Parity

  

0.49

  

0.24

 0

28 (93.3)

30 (100)

 

37 (92.5)

40 (100)

 

  ≥ 1

2 (6.7)

0 (0)

 

3 (7.5)

0 (0)

 

Maternal age (years)

 

0.62

  

0.25

  < 25

4 (13.3)

3 (10.0)

 

3 (7.5)

2 (5.0)

 

 25–29

14 (46.7)

18 (60.0)

 

21 (52.5)

21 (52.5)

 

 30–34

7 (23.3)

7 (23.3)

 

16 (40.0)

13 (32.5)

 

  ≥ 35

5 (16.7)

2 (6.7)

 

0 (0)

4 (10.0)

 

Pre-pregnancy BMI (kg/m2)

  

0.73

  

0.74

  < 18.5

6 (20.0)

4 (13.3)

 

8 (20.0)

5 (12.5)

 

 18.5–24.9

24 (80.0)

25 (83.3)

 

29 (72.5)

30 (75.0)

 

 25.0–29.9

0 (0)

1 (3.3)

 

3 (7.5)

4 (10.0)

 

  ≥ 30

0 (0)

0 (0)

 

0 (0)

1 (2.5)

 

Han ethnicity

29 (96.7)

28 (93.3)

1.00

40 (100)

39 (97.5)

1.00

Male fetus

10 (33.3)

16 (53.3)

0.19

22 (55.0)

23 (57.5)

1.00

Maternal education

 

0.24

  

0.09

 High school and below

2 (6.7)

2 (6.7)

 

8 (20.0)

2 (5.0)

 

 College

21 (70.0)

26 (86.7)

 

31 (77.5)

37 (92.5)

 

 Postgraduate

7 (23.3)

2 (6.7)

 

1 (2.5)

1 (2.5)

 
  1. Note: Data presented are mean ± standard deviation, or n (%)
  2. Fisher’s Exact test, or Student’s t test was used to compare the difference of characteristics between VD and CDMR