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Table 3 Hazard ratios of different categories of macrosomia, with and without diabetes for incident CKD

From: Macrosomia is a risk factor for incident maternal chronic kidney disease

 

Model 1

Model 2

Model 3

 

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

Study groups (n)

-  No diabetes (2380)

Reference

 

Reference

 

Reference

 

-  Macrosomia (176)

2.0(1.54–2.59)

< 0.001

1.37 (1.06–1.78)

0.017

1.36 (1.04–1.78)

0.023

-  NDM (113)

1.45(1.03–2.05)

0.035

0.80 (0.56–1.43)

0.22

0.74 (0.52–1.07)

0.111

Age, years

–

–

1.10(1.09–1.11)

< 0.001

1.06 (1.04–1.08)

<  0.001

BMI (Kg/m2)

–

–

–

–

1.01 (0.98–1.05)

0.43

WC (cm)

    

0.99 (0.98–1.01)

0.38

Parity

    

0.98 (0.92–1.06)

0.68

Smoking status

-  Never

–

–

–

–

Reference

 

-  Former

    

0.87 (0.36–2.10)

0.75

-  Current smoker

–

–

–

–

1.42 (1.00–2.00)

<  0.001

Education

-   < 6 years

–

–

–

–

Reference

 

-  6–12 years

–

–

–

–

1.20 (0.98–1.47)

0.078

-   ≥ 12 years

–

–

–

–

1.18 (0.84–1.66)

0.34

Gestational hypertension

–

–

–

–

0.97 (0.92–1.03)

0.37

eGFR (ml/min/1.73 m2)

–

–

–

–

0.91 (0.90–0.92)

<  0.001

SBP (mmHg)

–

–

–

–

1.01 (1.00–1.02)

0.042

DBP (mmHg)

–

–

–

–

0.99 (0.98–1.01)

0.26

Anti-hypertensive medication

–

–

–

–

0.99 (0.64–1.53)

0.96

FH-DM

–

–

–

–

1.02 (0.85–1.21)

0.90

  1. Model 1: Study groups (unadjusted model)
  2. Model 2: adjusted for baseline age
  3. Model 3: adjusted for baseline age, BMI, WC, number of parities, smoking status, educational level, gestational hypertension, eGFR, SBP, DBP, anti-hypertensive medication, and FH-DM
  4. Abbreviations: NDM: newly diagnosed type 2 diabetes mellitus; CKD, chronic kidney disease; HR, hazard ratio; CI, confidence interval; n, number; BMI, body mass index; WC, waist circumference; eGFR, estimated glomerular filtration rate; SBP, systolic blood pressure; DBP, diastolic blood pressure; FH-DM, family history of diabetes mellitus