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Table 2 Maternal Frailty (MaFra) Inventory. Intrauterine and extrauterine preterm birth risk factors included in the MaFra Inventory. 150 items assess the 71 listed factors while 24 Items collect more general sociodemographic, anamnestic and basic pregnancy history information for a total of 174 items included in the MaFra Inventory

From: A hierarchical procedure to select intrauterine and extrauterine factors for methodological validation of preterm birth risk estimation

System

Pregnancy anamnesis

Factors

Number of items

High/ low risk

Uterine environment

Study

UTERINE

PREVIOUS (Conditions of Pregnancy)

Parity

1

L

U

[34]

UTERINE

PREVIOUS (Conditions of Pregnancy)

Delivery Onset

2

L

U

[35]

UTERINE

PREVIOUS (Conditions of Pregnancy)

Breastfeeding

1

L

U

[36]

UTERINE

PREVIOUS (Conditions of Pregnancy)

Multiple Gestation

1

L

U

[37]

UTERINE

PREVIOUS (Conditions of Pregnancy)

Voluntary Interruption of Pregnancy

1

L

U

[38]

UTERINE

PREVIOUS (Conditions of Pregnancy)

Miscarriage

1

L

U

[38]

UTERINE

PREVIOUS (Conditions of Pregnancy)

Prior PTB

2

H

U

[4]

UTERINE

CURRENT (Conditions of Pregnancy)

Fetal Growth Restriction

9

H

F

[9]

UTERINE

CURRENT (Conditions of Pregnancy)

Medically Assisted Procreation

2

H

U

[22]

UTERINE

CURRENT (Conditions of Pregnancy)

Short Cervical Length

1

H

U

[19]

UTERINE

CURRENT (Conditions of Pregnancy)

Placenta Previa

1

H

P

[24]

UTERINE

CURRENT (Conditions of Pregnancy)

Placental Abruption

1

H

P

[5]

UTERINE

CURRENT (Conditions of Pregnancy)

Uterine Fibroid (Leiomyomas)

1

L

U

[39]

UTERINE

CURRENT (Conditions of Pregnancy)

Polidramnios

1

H

U

[20]

UTERINE

CURRENT (Conditions of Pregnancy)

Oligoidramnios

1

L

U

[40]

UTERINE

CURRENT (Conditions of Pregnancy)

Fetal Fibronectin

1

H

F

[41]

UTERINE

CURRENT (Conditions of Pregnancy)

Interleukin (IL)-6-Inflammatory Cytokine

1

H

U

[42]

UTERINE

CURRENT (Conditions of Pregnancy)

Fetal Sex

1

L

F

[43]

UTERINE

CURRENT (Conditions of Pregnancy)

Pregnancy Induced Hypertension (PIH)

1

H

P

[44]

UTERINE

CURRENT (Conditions of Pregnancy)

Preeclampsia

3

H

P

[45]

EXTRAUTERINE

CURRENT (Conditions of Pregnancy)

Pregnancy Awareness

10

L

-

[46]

EXTRAUTERINE

CURRENT (Conditions of Pregnancy)

Obesity

4

L

-

[47]

EXTRAUTERINE

CURRENT (Conditions of Pregnancy)

Gestational Diabetes

2

L

-

[48]

EXTRAUTERINE

CURRENT (Conditions of Pregnancy)

Thyroid Disease

2

L

-

[49]

EXTRAUTERINE

CURRENT (Conditions of Pregnancy)

Autoimmune Syndrome

1

H

-

[27]

EXTRAUTERINE

CURRENT (Conditions of Pregnancy)

Urinary Tract Infection (UTI)

1

H

-

[26]

EXTRAUTERINE

CURRENT (Conditions of Pregnancy)

Fever

1

L

-

[50]

EXTRAUTERINE

CURRENT (Conditions of Pregnancy)

Rubella

1

L

-

[51]

EXTRAUTERINE

CURRENT (Conditions of Pregnancy)

Infection

4

L

-

[52]