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Table 3 Review of pregnancy cases with adult onset Still’s disease classified into three types

From: A case of recurrence of adult-onset Still’s disease in the third trimester: a case report and literature review

Total: 47 pregnant women and 53 pregnancies
  First onset (Number = 26) Recurrent flare (Number = 13) No flare (Number = 14)
Age at pregnancy (year), Median [IQR] 29 [25–33] (1 unknown case) 31 [29–34] 27 [26–30] (1 unknown case)
Parity, %
 Primigravida 50 (8/16) 80 (8/10) 69.2 (9/13)
 Multigravida 50 (8/16) 20 (2/10) 30.8 (4/13)
 Unknown, number 10 3 1
Timing of flare, %
 1st trimester 24 (6/25) 23.1 (3/13)
 2nd trimester 52 (13/25) 38.5 (5/13)
 3rd trimester 8 (2/25) 7.7 (1/13)
 Postpartum 16 (4/25) 30.8 (4/13)
 Unknown, number 1 0
Major symptoms and complications, %
 Fever 95.7 (22/23) 70 (7/10)
 Arthralgia, Arthritis 91.3 (21/23) 60 (6/10)
 Erythema, Rash 78.3 (18/23) 50 (5/10)
 Sore throat 65.2 (15/23) 30 (3/10)
 Lymphadenopathy 60.9 (14/23) 10 (1/10)
 Hepatomegaly, Liver dysfunction 34.8 (8/23) 30 (3/10)
 Splenomegaly 34.8 (8/23) 10 (1/10)
 HLH 8.7 (2/23) 10 (1/10)
 Unknown, number 3 3
Major treatment, %
Corticosteroid 82.6 (19/23) 69.2 (9/13) 28.6 (4/14)
 Anakinra 13.0 (3/23) 7.7 (1/13) 28.6 (4/14)
 IVIg 17.4 (4/23) 7.7 (1/13) 7.1 (1/14)
 NSAIDs 21.7 (5/23) 7.7 (1/13) 14.3 (2/14)
 HCQ 4.3 (1/23) 15.4 (2/13) 7.1 (1/14)
 No medication 57.1 (8/14)
 Unknown, number 3 0 0
Delivery, %
 Transvaginal 66.7 (12/18) 50 (4/8) 62.5 (5/8)
 Cesarean section 22.2 (4/18) 50 (4/8) 25 (2/8)
 Abortion 11.1 (2/18) 0 (0/8) 12.5 (1/8)
 Unknown, number 8 5 6
Major obstetrical and perinatal complications, %
 Preterm birth 32 (8/25) 33.3 (4/12) 16.7 (2/12)
 IUGR 8 (2/25) 41.7 (5/12) 8.3 (1/12)
 pPROM 12 (3/25) 8.3 (1/12) 8.3 (1/12)
 No major complication 48 (12/25) 41.7 (5/12) 50 (6/12)
 Others, number 2 for OHD, 1 for neonatal HLH, 1 for preeclampsia, and 1 for neonatal death for IRDS 1 for GDM, and 1 for OHD 1 for neonatal HLH, 1 for GDM, and 1 for HDP
 Unknown, number 1 1 2