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Table 1 Characteristics of trial participants stratified to treatment allocation (prophylactic metformin or placebo) after antenatal corticosteroids

From: Prophylactic metformin after antenatal corticosteroids (PROMAC): a double blind randomized controlled trial

  Metformin
n = 52
Placebo
n = 51
p value
Age (years) 31.3 ± 4.4 31.0 ± 3.4 0.71
Recruitment capillary glucose (mmol/L) 5.1 ± 0.8 5.0 ± 0.9 0.85
Recruitment gestational age (weeks) 33.7 [32.1-35-1] 34.7 [32.6–36.4] 0.11
Nulliparous 27 (51.9 %) 26 (51.0 %) 0.92
Height (m) 1.57 ± 0.05 1.57 ± 0.04 0.99
Weight (kg) 72.2 ± 13.9 70.6 ± 14.7 0.55
Body mass index (kg/m2) 29.2 ± 5.6 28.4 ± 5.5 0.48
Gestational diabetes    0.88
 Non-GDM 36 (69.2 %) 36 (70.6 %)  
 GDM 16 (30.8 %) 15 (29.4 %)  
Indication for antenatal dexamethasone    0.82
 Suspected preterm labor 16 (30.8 %) 14 (27.5 %)  
 Antepartum hemorrhage 10 (19.2 %) 13 (25.5 %)  
 Non-reassuring fetal status 13 (25.0 %) 10 (19.6 %)  
Othersa 13 (25.0 %) 14 (27.5 %)  
 Ethnicity    0.65
 Malay 35 (67.3 %) 34 (66.7 %)  
 Chinese 7 (13.5 %) 4 (7.8 %)  
 Indian 6 (11.5 %) 6 (11.8 %)  
Othersb 4 (7.7 %) 7 (13.7 %)  
 1st dose dexamethasone to study drug (hours) 4.5 [3.0-5.5] 4 [2-5] 0.22
First blood sugar profile point within trial n = 48 n = 50  
Before breakfast 5 (10.4 %) 2 (4.0 %) 0.10
2-hour after breakfast 5 (10.4 %) 6 (12.0 %)  
Before lunch 8 (16.7 %) 6 (12.0 %)  
2-hour after lunch 14 (29.2 %) 6 (12.0 %)  
Before dinner 9 (18.8 %) 18 (36 %)  
2-hour after dinner 7 (14.6 %) 12 (24.0 %)  
  1. Data expressed as mean ± standard deviation, median [interquartile range] and number (%). Analyses by Student t test for comparison of means for normally distributed continuous data and by Mann-Whitney U test for non-parametric or ordinal data and Chi Square test for categorical data
  2. aOther indications: 11 maternal hypertension, 9 planned Cesarean section, 5 preterm prelabor rupture of membrane, 1 reduced fetal movement, 1 pulmonary embolism
  3. bOther ethnicities: 2 Sabah native, 4 Vietnamese, 1 Filipino, 1 Pakistani, 1 Yemeni, 1 Indonesian and 1 Syrian
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