Table 1 Characteristics of trial participants stratified to treatment allocation (prophylactic metformin or placebo) after antenatal corticosteroids
Metformin n = 52 | Placebo n = 51 | p value | |
|---|---|---|---|
Age (years) | 31.3 ± 4.4 | 31.0 ± 3.4 | 0.71 |
Recruitment capillary glucose (mmol/L) | 5.1 ± 0.8 | 5.0 ± 0.9 | 0.85 |
Recruitment gestational age (weeks) | 33.7 [32.1-35-1] | 34.7 [32.6–36.4] | 0.11 |
Nulliparous | 27 (51.9 %) | 26 (51.0 %) | 0.92 |
Height (m) | 1.57 ± 0.05 | 1.57 ± 0.04 | 0.99 |
Weight (kg) | 72.2 ± 13.9 | 70.6 ± 14.7 | 0.55 |
Body mass index (kg/m2) | 29.2 ± 5.6 | 28.4 ± 5.5 | 0.48 |
Gestational diabetes | 0.88 | ||
Non-GDM | 36 (69.2 %) | 36 (70.6 %) | |
GDM | 16 (30.8 %) | 15 (29.4 %) | |
Indication for antenatal dexamethasone | 0.82 | ||
Suspected preterm labor | 16 (30.8 %) | 14 (27.5 %) | |
Antepartum hemorrhage | 10 (19.2 %) | 13 (25.5 %) | |
Non-reassuring fetal status | 13 (25.0 %) | 10 (19.6 %) | |
Othersa | 13 (25.0 %) | 14 (27.5 %) | |
Ethnicity | 0.65 | ||
Malay | 35 (67.3 %) | 34 (66.7 %) | |
Chinese | 7 (13.5 %) | 4 (7.8 %) | |
Indian | 6 (11.5 %) | 6 (11.8 %) | |
Othersb | 4 (7.7 %) | 7 (13.7 %) | |
1st dose dexamethasone to study drug (hours) | 4.5 [3.0-5.5] | 4 [2-5] | 0.22 |
First blood sugar profile point within trial | n = 48 | n = 50 | |
Before breakfast | 5 (10.4 %) | 2 (4.0 %) | 0.10 |
2-hour after breakfast | 5 (10.4 %) | 6 (12.0 %) | |
Before lunch | 8 (16.7 %) | 6 (12.0 %) | |
2-hour after lunch | 14 (29.2 %) | 6 (12.0 %) | |
Before dinner | 9 (18.8 %) | 18 (36 %) | |
2-hour after dinner | 7 (14.6 %) | 12 (24.0 %) |