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Table 2 Association between VDR gene SNPs and the risk of GDM

From: Association of vitamin D receptor gene polymorphisms with gestational diabetes mellitus-a case control study in Wuhan, China

Ā 

GDM (nā€‰=ā€‰826)

Non-GDM (nā€‰=ā€‰858)

Crude OR (95ā€‰% CI)

Crude P

Adjusted OR (95ā€‰% CI)

Adjusted P

rs2228570

Ā Codominant model

Ā Ā GG

219

230

1(ref.)

Ā 

1(ref.)

Ā 

Ā Ā GA

389

415

0.98(0.78ā€“1.24)

0.89

0.92(0.70ā€“1.21)

0.53

Ā Ā AA

206

203

1.07(0.82ā€“1.39)

0.64

2.40(0.73ā€“1.38)

0.99

Ā Dominant Model

Ā Ā GG

219

230

1(ref.)

Ā 

1(ref.)

Ā 

Ā Ā GAā€‰+ā€‰AA

595

618

1.01(0.81ā€“1.26)

0.92

0.94(0.73ā€“1.22)

0.66

Ā Recessive Model

Ā Ā GGā€‰+ā€‰GA

608

645

1(ref.)

Ā 

1(ref.)

Ā 

Ā Ā AA

206

203

1.08(0.86ā€“1.35)

0.52

1.06(0.81ā€“1.38)

0.67

Ā Overdominant model

Ā Ā GGā€‰+ā€‰AA

425

433

1(ref.)

Ā 

1(ref.)

Ā 

Ā Ā GA

389

415

0.96(0.79ā€“1.16)

0.64

0.92(0.73ā€“1.15)

0.45

rs1544410

Ā Codominant model

Ā Ā CC

752

776

1(ref.)

Ā 

1(ref.)

Ā 

Ā Ā CT

63

69

0.94(0.66ā€“1.35)

0.74

0.98(0.65ā€“1.49)

0.92

Ā Ā TT

3

3

1.03(0.21ā€“5.13)

0.97

0.64(0.13ā€“3.19)

0.58

Ā Dominant Model

Ā Ā CC

752

776

1(ref.)

Ā 

1(ref.)

Ā 

Ā Ā CTā€‰+ā€‰TT

66

72

0.95(0.67ā€“1.34)

0.76

0.96(0.64ā€“1.43)

0.82

Ā Recessive Model

Ā Ā CCā€‰+ā€‰CT

815

845

1(ref.)

Ā 

1(ref.)

Ā 

Ā TT

3

3

1.04(0.21ā€“5.15)

0.97

0.64(0.13ā€“3.20)

0.58

Ā Ā Overdominant model

Ā Ā CCā€‰+ā€‰TT

755

779

1(ref.)

Ā 

1(ref.)

Ā 

Ā Ā CT

63

69

0.94(0.66ā€“1.35)

0.74

0.98(0.65ā€“1.49)

0.93

rs739837

Ā Codominant model

Ā Ā GG

414

447

1(ref.)

Ā 

1(ref.)

Ā 

Ā Ā GT

324

327

1.07(0.87ā€“1.31)

0.52

1.10(0.86ā€“1.41)

0.44

Ā Ā TT

78

77

1.09(0.78ā€“1.54)

0.61

1.12(0.80ā€“1.66)

0.56

Ā Dominant Model

Ā Ā Ā Ā Ā Ā 

Ā Ā GG

414

447

1(ref.)

Ā 

1(ref.)

Ā 

Ā Ā GTā€‰+ā€‰TT

402

404

1.07(0.89ā€“1.30)

0.46

1.1(0.88ā€“1.39)

0.39

Ā Recessive Model

Ā Ā GGā€‰+ā€‰GT

738

774

1(ref.)

Ā 

1(ref.)

Ā 

Ā Ā TT

78

77

1.06(0.76ā€“1.48)

0.72

1.08(0.74ā€“1.57)

0.70

Ā Overdominant model

Ā Ā GGā€‰+ā€‰TT

492

524

1(ref.)

Ā 

1(ref.)

Ā 

Ā Ā GT

324

327

1.06(0.87ā€“1.28)

0.59

1.08(0.85ā€“1.37)

0.52

rs731236

Ā Codominant model

Ā Ā AA

745

778

1(ref.)

Ā 

1(ref.)

Ā 

Ā Ā GA

68

67

1.06(0.75ā€“1.51)

0.75

1.16(0.77ā€“1.75)

0.48

Ā Ā GG

4

4

1.04(0.26ā€“4.19)

0.95

0.49(0.1ā€“2.21)

0.35

Ā Dominant Model

Ā Ā AA

745

778

1(ref.)

Ā 

1(ref.)

Ā 

Ā Ā GAā€‰+ā€‰GG

72

71

1.06(0.75ā€“1.49)

0.74

1.10(0.74ā€“1.64)

0.65

Ā Recessive Model

Ā Ā AAā€‰+ā€‰GA

813

845

1(ref.)

Ā 

1(ref.)

Ā 

Ā Ā GG

4

4

1.04(0. 26-4.17)

0.96

0.48(0.1ā€“2.18)

0.34

Ā Overdominant model

Ā Ā AAā€‰+ā€‰GG

749

782

1(ref.)

Ā 

1(ref.)

Ā 

Ā GA

68

67

1.06(0.75ā€“1.51)

0.75

1.17(0.77ā€“1.76)

0.47

rs7975232

Ā Codominant model

Ā Ā CC

415

446

1(ref.)

Ā 

1(ref.)

Ā 

Ā Ā CA

324

328

1.06(0.87ā€“1.30)

0.57

1.10(0.86ā€“1.40)

0.47

Ā Ā AA

77

74

1.12(0.79ā€“1.58)

0.53

1.19(0.79ā€“1.77)

0.40

Ā Dominant Model

Ā Ā CC

415

446

1(ref.)

Ā 

1(ref.)

Ā 

Ā Ā CAā€‰+ā€‰AA

401

402

1.07(0. 88ā€‰āˆ’ā€‰1.30)

0.48

1.11(0.89ā€“1.40)

0.36

Ā Recessive Model

Ā Ā CCā€‰+ā€‰CA

739

774

1(ref.)

Ā 

1(ref.)

Ā 

Ā Ā AA

77

74

1.09(0. 78-1.52)

0.61

1.14(0.78ā€“1.68)

0.50

Ā Overdominant model

Ā Ā CCā€‰+ā€‰AA

492

520

1(ref.)

Ā 

1(ref.)

Ā 

Ā CA

324

328

1.04(0.86ā€“1.27)

0.67

1.07(0.84ā€“1.35)

0.60

  1. Adjusted OR is adjusted for age, pre-pregnancy BMI, family history of diabetes.
  2. Abbreviations: VDRĀ vitamin D receptor; SNPsĀ single nucleotide polymorphisms; GDMĀ gestational diabetes mellitus; BMIĀ body mass index; ORĀ odds ratio; CIĀ confidence interval; refĀ reference genotype