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Table 1 Patient demographics, duration of and reasons for infertility and cycle characteristics before and after regulations

From: Incidence of multiple births in relation to current regulations in Turkey regarding embryo transfer

 

2003-April 2010

n = 12,741

April 2010–July 2019

n = 18,718

P-value

Age, years, mean ± SD

32.63 ± 5.55

33.24 ± 5.37

a < 0.001*

Maternal BMI (kg/m2), mean ± SD

25.48 ± 4.54

25.04 ± 4.53

a < 0.001*

Previous cycle number, mean ± SD

2.29 ± 1.69

3.48 ± 2.69

a < 0.001*

Duration of infertility, years, mean ± SD

7.59 ± 5.38

5.74 ± 4.54

a < 0.001*

Infertility cause, n (%)

 Male Factor

4399 (34.5)

6219 (33.2)

b0.016*

 Diminished ovarian reserve

1742 (13.6)

3478 (18.5)

b < 0.001*

 Endometriosis

424 (3.3)

734 (3.9)

b0.006*

 Ovulatory dysfunction

1073 (8.4)

1057 (5.6)

b < 0.001*

 Genetics

652 (5.1)

875 (4.7)

b0.08

 Recurrent spontaneous abortion

321 (2.5)

839 (4.5)

b < 0.001*

 Tubal Factor

1796 (14.0)

2301 (12.3)

b < 0.001*

 Unexplained infertility

2334 (18.3)

3215 (17.2)

b0.01*

Number of aspirated oocytes, mean ± SD

12.90 ± 7.81

11.62 ± 8.63

a < 0.001*

MII, mean ± SD

9.39 ± 5.98

9.33 ± 7.03

a0.406

PN2, mean ± SD

7.37 ± 4.48

7.81 ± 6.01

a < 0.001*

Number of embryos transferred, n (%)

 1

1803 (14.1)

10,600 (56.6)

 

 2

4105 (32.2)

8120 (43.4)

 

 3

4025 (31.6)

 

 4

1916 (15.0)

 

 5

882 (6.8)

 

Embryo transfer day, n (%)

 D2–3

5977 (46.9)

2647 (14.1)

 

 D4

3448 (27.0)

2225 (11.9)

 

 D5–6

3316 (26.1)

13,846 (74)

 
  1. BMI Body mass index, MII Maturated oocytes, PN2 Normally fertilized oocytes
  2. aIndependent Two Samples t-Test bChi-Square Test *p < 0,05