From: Incidence of multiple births in relation to current regulations in Turkey regarding embryo transfer
2003-April 2010 n = 12,741 | April 2010–July 2019 n = 18,718 | P-value | |
---|---|---|---|
Age, years, mean ± SD | 32.63 ± 5.55 | 33.24 ± 5.37 | a < 0.001* |
Maternal BMI (kg/m2), mean ± SD | 25.48 ± 4.54 | 25.04 ± 4.53 | a < 0.001* |
Previous cycle number, mean ± SD | 2.29 ± 1.69 | 3.48 ± 2.69 | a < 0.001* |
Duration of infertility, years, mean ± SD | 7.59 ± 5.38 | 5.74 ± 4.54 | a < 0.001* |
Infertility cause, n (%) | |||
Male Factor | 4399 (34.5) | 6219 (33.2) | b0.016* |
Diminished ovarian reserve | 1742 (13.6) | 3478 (18.5) | b < 0.001* |
Endometriosis | 424 (3.3) | 734 (3.9) | b0.006* |
Ovulatory dysfunction | 1073 (8.4) | 1057 (5.6) | b < 0.001* |
Genetics | 652 (5.1) | 875 (4.7) | b0.08 |
Recurrent spontaneous abortion | 321 (2.5) | 839 (4.5) | b < 0.001* |
Tubal Factor | 1796 (14.0) | 2301 (12.3) | b < 0.001* |
Unexplained infertility | 2334 (18.3) | 3215 (17.2) | b0.01* |
Number of aspirated oocytes, mean ± SD | 12.90 ± 7.81 | 11.62 ± 8.63 | a < 0.001* |
MII, mean ± SD | 9.39 ± 5.98 | 9.33 ± 7.03 | a0.406 |
PN2, mean ± SD | 7.37 ± 4.48 | 7.81 ± 6.01 | a < 0.001* |
Number of embryos transferred, n (%) | |||
1 | 1803 (14.1) | 10,600 (56.6) | |
2 | 4105 (32.2) | 8120 (43.4) | |
3 | 4025 (31.6) | – | |
4 | 1916 (15.0) | – | |
5 | 882 (6.8) | – | |
Embryo transfer day, n (%) | |||
D2–3 | 5977 (46.9) | 2647 (14.1) | |
D4 | 3448 (27.0) | 2225 (11.9) | |
D5–6 | 3316 (26.1) | 13,846 (74) |