Table 3 Univariate analysis of factors associated with neonatal hyperbilirubinemia (NH) requiring phototherapy

Continuous Variables

No NH

NH

Crude OR (95% CI)

p value

 Ketamine dose (mg/kg)^a N = 287

1.33 [0.46–3.80]

1.40 [0–3.07]

1.32 (0.65–2.68)

0.429

 IV diazepam dose (mg/10 kg)^a N = 287

1.34 [0–4.35]

1.85 [0–6.15]

1.83 (1.22–2.74)

0.003

 Lidocaine dose (mg)^a N = 285

105.86 [50–200]

108.29 [90–200]

1.00 (0.99–1.02)

0.571

Categorical Variables

Percent (n) NH

Crude OR (95% CI)

p value

 PO diazepam N = 291

No

13.0 (19/146)

Reference group

Yes

11.0 (16/145)

0.83 (0.41–1.68)

0.604

 Karen Ethnicity N = 292

No

12.8 (20/156)

Reference group

Yes

11.0 (15/136)

0.84 (0.41–1.72)

0.639

 Pre-eclampsia N = 292

No

11.4 (30/263)

Reference group

Yes

17.2 (5/29)

1.62 (0.57–4.56)

0.363

 Maternal obesity N = 292

No

10.4 (27/260)

Reference group

Yes

25.0 (8/32)

2.88 (1.18–7.03)

0.021

 Infant sex N = 292

Male

11.3 (18/159)

Reference group

Female

12.8 (17/133)

1.15 (0.57–2.33)

0.702

 EGA at birth N = 292

≥ 39 wks

9.5 (21/222)

Reference group

37- < 39 wks

20.0 (14/70)

2.39 (1.14–5.01)

0.021

 Weight loss ≥95^thpercentile 1st post-operative day N = 292

No

11.7 (32/274)

Reference group

Yes

16.7 (3/18)

1.51 (0.42–5.51)

0.531

 Year of birth N = 292

2013–2015

13.2 (23/174)

Reference group

2016–2018

10.2 (12/118)

0.74 (0.35–1.56)

0.432

 Postpartum day of tubal ligation N = 292

0–2

12.1 (26/214)

Reference group

3–7

11.5 (9/78)

0.94 (0.42–2.11)

0.887

 G6PD deficiency N = 100

No

26.7 (23/86)

Reference group

Yes

64.3 (9/14)

4.93 (1.50–16.25)

0.009