Gestational systolic blood pressure trajectories and risk of adverse maternal and perinatal outcomes in Chinese women

Table 4 Reclassification and Discrimination Statistics of adverse maternal and perinatal outcomes based on SBP trajectory

Clinical outcomes	Model	C statistics		Continuous NRI, %		IDI, %
Clinical outcomes	Model	Estimate (95% CI)	P value	Estimate (95% CI)	P value	Estimate (95% CI)	P value
GH	Model 3	0.835 (0.818 to 0.852)		Reference		Reference
GH	Model 3+ trajectory categories	0.859 (0.844 to 0.874)	< 0.001	14.25 (0.53 to 0.68)	< 0.001	2.98 (0.002 to 0.01)	0.003
PTD	Model 4	0.833 (0.823 to 0.842)		Reference		Reference
PTD	Model 4+ trajectory categories	0.834 (0.824 to 0.843)	0.151	4.76 (0.09 to 0.22)	< 0.001	2.63 (0.0002 to 0.002)	0.009
ETD	Model 4	0.665 (0.657 to 0.673)		Reference		Reference
ETD	Model 4+ trajectory categories	0.666 (0.658 to 0.674)	0.038	2.83 (0.01 to 0.07)	< 0.001	4.36 (0.001 to 0.002)	< 0.001
SGA	Model 4	0.655 (0.642 to 0.668)		Reference		Reference
SGA	Model 4+ trajectory categories	0.657 (0.643 to 0.670)	0.171	3.12 (0.03 to 0.13)	0.002	2.94 (0.0002 to 0.001)	0.003
LBW	Model 4	0.665 (0.657 to 0.658)		Reference		Reference
LBW	Model 4+ trajectory categories	0.666 (0.658 to 0.674)	0.038	3.59 (0.08 to 0.26)	0.0003	2.77 (0.0004 to 0.002)	0.006

NRI net reclassification improvement, IDI integrated discrimination index, CI confidence interval, GH gestational hypertension, ETD early-term delivery, PTD pre-term delivery, SGA small for gestational age, LBW low birth weight
Model 3 included maternal age at delivery (in years, continuous), early pregnancy BMI (Kg/m2, continuous), gestation, parity, presence of GDM, SBP (mmHg, continuous) at the first visit, and SBP measurement times (continuous) during pregnancy;
Model 4 was additionally controlled for infant sex (boys, girls) and presence of hypertensive disorders in pregnancy (including GH, PE and eclampsia), on the basis of Model 3

ISSN: 1471-2393