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Table 3 Descriptive statistics of 26 clinical features of ICP individuals associated with/without 42 novel mutations

From: Whole-exome sequencing identifies novel mutations in ABC transporter genes associated with intrahepatic cholestasis of pregnancy disease: a case-control study

Features ICP with 42 novel mutations ICP without 42 novel mutations  
N Mean SD Min. Max. N Mean SD Min Max P
Basic information
 Age (years) 37 29.54 5.75 17.00 41.00 113 29.35 5.12 20.00 43.00 0.84
 Gestational age (days) 34 254.03 22.68 196.00 290.00 110. 260.04 18.05 204.00 290.00 0.06
 BMI (kg/m2) 31 26.91 3.78 21.50 36.30 106 25.46 3.22 19.60 38.50 0.037
Ion concentrations
 K (mmol/L) 34 4.04 0.30 3.60 4.90 106 3.99 0.32 3.20 4.80 0.44
 Na (mmol/L) 34 137.71 2.70 133.00 143.00 105 137.36 2.27 132.00 143.00 0.47
 Cl (mmol/L) 34 104.26 2.81 97.00 110.00 105 104.08 2.80 98.00 112.00 0.73
 Ca (mmol/L) 34 2.31 0.15 2.09 2.80 105 2.31 0.16 2.00 2.90 0.86
 Mg (mmol/L) 34 0.80 0.10 0.60 1.10 105 0.82 0.16 0.65 1.89 0.36
 P (mmol/L) 34 1.10 0.17 0.72 1.50 105 1.13 0.18 0.70 1.60 0.51
Routine blood tests
 WBC (×109) 36 8.21 1.97 4.94 13.36 113 8.66 3.07 4.37 24.23 0.30
 RBC (×109) 36 3.89 0.44 3.24 4.98 113 3.82 0.41 2.96 4.81 0.39
 PLT (×109) 36 196.33 62.49 87.00 412.00 113 198.81 63.24 75.00 377.00 0.84
 RDW.SD (fL) 36 45.23 5.73 36.90 67.30 113 46.08 4.28 36.20 62.40 0.41
Liver function indexes
 ALT (U/L) 37 90.81 126.35 3.00 452.00 113 95.77 125.18 4.00 595.00 0.83
 AST (U/L) 37 76.35 88.34 12.00 359.00 113 83.08 97.35 12.00 456.00 0.71
 TBA (μmol/L) 37 40.58 21.96 12.50 105.80 113 44.73 44.17 10.70 286.80 0.42
 TBIL (μmol/L) 36 14.99 8.02 6.90 41.90 112 14.85 7.54 5.70 64.80 0.92
 DBIL (μmol/L) 36 6.42 6.06 2.00 28.80 112 6.44 5.98 0.90 49.50 0.99
 IDBIL (μmol/L) 36 8.57 4.41 3.50 26.90 112 8.43 3.30 2.90 23.40 0.86
Lipid index
 CHOL (mmol/L) 35 6.35 1.66 3.35 10.50 108 6.40 1.43 3.75 10.95 0.87
 TG (mmol/L) 35 3.78 1.65 2.11 10.44 108 3.54 1.54 1.20 11.10 0.44
 HDL (mmol/L) 35 1.95 0.54 1.28 4.06 108 1.89 0.40 0.92 3.19 0.59
 LDL (mmol/L) 35 2.68 1.41 0.19 5.96 108 2.89 1.21 0.13 6.28 0.39
 Uric acid (μmol/L) 34 313.74 91.93 131.00 574.00 106 322.41 78.30 111.00 498.00 0.59
Outcomes of pregnant women and newborns
 Birth weight (kg) 28 3.04 0.71 1.48 5.30 91 3.04 0.57 1.23 4.10 0.97
 Bleeding amount (ml) 28 240.36 62.63 150.00 400.00 86 258.84 102.10 90.00 810.00 0.27
  1. BMI body mass index, WBC white blood cell, RBC red blood cell, PLT platelet, RDW.SD red blood cell distribution width.SD, ALT alanine transaminase, AST aspartate transaminase, TBA total bile acids, TBIL total bilirubin, DBIL direct bilirubin, IDBIL indirect bilirubin, CHOL total cholesterol, TG triglyceride, HDL high-density lipoprotein, LDL low-density lipoprotein
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