Table 3 Descriptive statistics of 26 clinical features of ICP individuals associated with/without 42 novel mutations
Features | ICP with 42 novel mutations | ICP without 42 novel mutations | Â | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
N | Mean | SD | Min. | Max. | N | Mean | SD | Min | Max | P | |
Basic information | |||||||||||
 Age (years) | 37 | 29.54 | 5.75 | 17.00 | 41.00 | 113 | 29.35 | 5.12 | 20.00 | 43.00 | 0.84 |
 Gestational age (days) | 34 | 254.03 | 22.68 | 196.00 | 290.00 | 110. | 260.04 | 18.05 | 204.00 | 290.00 | 0.06 |
 BMI (kg/m2) | 31 | 26.91 | 3.78 | 21.50 | 36.30 | 106 | 25.46 | 3.22 | 19.60 | 38.50 | 0.037 |
Ion concentrations | |||||||||||
 K (mmol/L) | 34 | 4.04 | 0.30 | 3.60 | 4.90 | 106 | 3.99 | 0.32 | 3.20 | 4.80 | 0.44 |
 Na (mmol/L) | 34 | 137.71 | 2.70 | 133.00 | 143.00 | 105 | 137.36 | 2.27 | 132.00 | 143.00 | 0.47 |
 Cl (mmol/L) | 34 | 104.26 | 2.81 | 97.00 | 110.00 | 105 | 104.08 | 2.80 | 98.00 | 112.00 | 0.73 |
 Ca (mmol/L) | 34 | 2.31 | 0.15 | 2.09 | 2.80 | 105 | 2.31 | 0.16 | 2.00 | 2.90 | 0.86 |
 Mg (mmol/L) | 34 | 0.80 | 0.10 | 0.60 | 1.10 | 105 | 0.82 | 0.16 | 0.65 | 1.89 | 0.36 |
 P (mmol/L) | 34 | 1.10 | 0.17 | 0.72 | 1.50 | 105 | 1.13 | 0.18 | 0.70 | 1.60 | 0.51 |
Routine blood tests | |||||||||||
 WBC (×109) | 36 | 8.21 | 1.97 | 4.94 | 13.36 | 113 | 8.66 | 3.07 | 4.37 | 24.23 | 0.30 |
 RBC (×109) | 36 | 3.89 | 0.44 | 3.24 | 4.98 | 113 | 3.82 | 0.41 | 2.96 | 4.81 | 0.39 |
 PLT (×109) | 36 | 196.33 | 62.49 | 87.00 | 412.00 | 113 | 198.81 | 63.24 | 75.00 | 377.00 | 0.84 |
 RDW.SD (fL) | 36 | 45.23 | 5.73 | 36.90 | 67.30 | 113 | 46.08 | 4.28 | 36.20 | 62.40 | 0.41 |
Liver function indexes | |||||||||||
 ALT (U/L) | 37 | 90.81 | 126.35 | 3.00 | 452.00 | 113 | 95.77 | 125.18 | 4.00 | 595.00 | 0.83 |
 AST (U/L) | 37 | 76.35 | 88.34 | 12.00 | 359.00 | 113 | 83.08 | 97.35 | 12.00 | 456.00 | 0.71 |
 TBA (μmol/L) | 37 | 40.58 | 21.96 | 12.50 | 105.80 | 113 | 44.73 | 44.17 | 10.70 | 286.80 | 0.42 |
 TBIL (μmol/L) | 36 | 14.99 | 8.02 | 6.90 | 41.90 | 112 | 14.85 | 7.54 | 5.70 | 64.80 | 0.92 |
 DBIL (μmol/L) | 36 | 6.42 | 6.06 | 2.00 | 28.80 | 112 | 6.44 | 5.98 | 0.90 | 49.50 | 0.99 |
 IDBIL (μmol/L) | 36 | 8.57 | 4.41 | 3.50 | 26.90 | 112 | 8.43 | 3.30 | 2.90 | 23.40 | 0.86 |
Lipid index | |||||||||||
 CHOL (mmol/L) | 35 | 6.35 | 1.66 | 3.35 | 10.50 | 108 | 6.40 | 1.43 | 3.75 | 10.95 | 0.87 |
 TG (mmol/L) | 35 | 3.78 | 1.65 | 2.11 | 10.44 | 108 | 3.54 | 1.54 | 1.20 | 11.10 | 0.44 |
 HDL (mmol/L) | 35 | 1.95 | 0.54 | 1.28 | 4.06 | 108 | 1.89 | 0.40 | 0.92 | 3.19 | 0.59 |
 LDL (mmol/L) | 35 | 2.68 | 1.41 | 0.19 | 5.96 | 108 | 2.89 | 1.21 | 0.13 | 6.28 | 0.39 |
 Uric acid (μmol/L) | 34 | 313.74 | 91.93 | 131.00 | 574.00 | 106 | 322.41 | 78.30 | 111.00 | 498.00 | 0.59 |
Outcomes of pregnant women and newborns | |||||||||||
 Birth weight (kg) | 28 | 3.04 | 0.71 | 1.48 | 5.30 | 91 | 3.04 | 0.57 | 1.23 | 4.10 | 0.97 |
 Bleeding amount (ml) | 28 | 240.36 | 62.63 | 150.00 | 400.00 | 86 | 258.84 | 102.10 | 90.00 | 810.00 | 0.27 |