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Fig. 5 | BMC Pregnancy and Childbirth

Fig. 5

From: Whole-exome sequencing identifies novel mutations in ABC transporter genes associated with intrahepatic cholestasis of pregnancy disease: a case-control study

Fig. 5

Effects of the ABCC2 Ser1342Tyr variant on the protein sequence and structure. a Distribution of the ABCC2 variants. ABCC2 is a 1545-amino acid protein containing two major nucleotide-binding functional domains (ATP binding cassette domains). The locations of two ABCC2 variants from whole-exome sequencing are shown in the protein sequence. b In silico comparison of the higher assembly of the reference and modified (Ser1342Tyr) ABCC2 protein models. The reference and Ser1342Tyr molecules are presented as gold and blue rounded ribbon structures, respectively. The enlarged image shows that the functional domains have small changes in the chemical bond lengths. DBD: DNA-binding domain. c Comparison of the expression level of the ABCC2 gene between two healthy controls and four patients with ICP. Different letters above the expression column denote significant differences (P < 0.05)

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