Association of thyroid antibodies status on the outcomes of pregnant women with hypothyroidism (maternal hypothyroidism on pregnancy outcomes, MHPO-4)

Table 6 Association of independent variables with premature birth adjusted for anti-thyroid peroxidase (Anti-TPO) and anti-thyroglobulin (Anti-TG) antibodies on multivariate logistic regression

	Unadjusted OR (95% CI)	P-value	Adjusted OR (95% CI)	P-value	Unadjusted OR (95% CI)	P-value	Adjusted OR (95% CI)	P-value
ANTI-THYROID PEROXIDASE					ANTI-THYROGLOBULIN
Yes	1	0.328	1	0.58	1	0.32	1	0.46
No	1.51 (0.65–3.47)	0.328	1.39 (0.57–3.39)	0.58	1.56 (0.69–3.55)	0.32	1.44 (0.43–3.64)	0.46
AGE GROUPS
Age 20–25	1				1
Age 26–30	3.124 (0.82–11.77)	0.19			3.124 (0.82–11.77)	0.19
Age 31–35	2.5 (0.87–2.43)				2.5 (0.87–2.43)
Age 36 and above	2.25 (0.67–7.53)				2.25 (0.67–7.53)
PARITY
Nulliparous	1				1
Primiparous	0.48(0.17–1.36)	0.30			0.48(0.17–1.36)	0.30
Biparous/mutiparous	0.54 (0.20–1.45)	0.30			0.54 (0.20–1.45)	0.30
BODY MASS INDEX
Underweight/Normal	1	0.529			1	0.529
Overweight/obese	1.31 (0.55–3.10)	0.529			1.31 (0.55–3.10)	0.529
PRE GESTATIONAL DIABETES
Yes	1.24 (0.22–6.74)	0.80			1.24 (0.22–6.74)	0.80
No	1	0.80			1	0.80
GESTATIONAL DIABETES
Yes	2.35 (0.93–5.92)	0.07			2.35 (0.93–5.92)	0.07
No	1	0.07			1	0.07
HYPERTENSION
No	1		1		1		1
Pre-eclampsia/ Gestational Hypertension	2. 65(1.81–8.63)	0.002	2.48 (0.72–8.53)	0.03*	2. 65(1.81–8.63)	0.002	2.46(0.83–8.77)	0.05*
Chronic Hypertension	12.74 (2.34–36.91)	0.002	12.71 (2.37–67.99)	0.03*	12.74 (2.34–36.91)	0.002	11.34 (2.63–64.34)

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