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Table 6 Association of independent variables with premature birth adjusted for anti-thyroid peroxidase (Anti-TPO) and anti-thyroglobulin (Anti-TG) antibodies on multivariate logistic regression

From: Association of thyroid antibodies status on the outcomes of pregnant women with hypothyroidism (maternal hypothyroidism on pregnancy outcomes, MHPO-4)

  Unadjusted OR (95% CI) P-value Adjusted OR (95% CI) P-value Unadjusted OR (95% CI) P-value Adjusted OR (95% CI) P-value
ANTI-THYROID PEROXIDASE ANTI-THYROGLOBULIN
Yes 1 0.328 1 0.58 1 0.32 1 0.46
No 1.51 (0.65–3.47) 1.39 (0.57–3.39) 1.56 (0.69–3.55) 1.44 (0.43–3.64)
AGE GROUPS
Age 20–25 1     1    
Age 26–30 3.124 (0.82–11.77) 0.19    3.124 (0.82–11.77) 0.19   
Age 31–35 2.5 (0.87–2.43)    2.5 (0.87–2.43)   
Age 36 and above 2.25 (0.67–7.53)    2.25 (0.67–7.53)   
PARITY
Nulliparous 1     1    
Primiparous 0.48(0.17–1.36) 0.30    0.48(0.17–1.36) 0.30   
Biparous/mutiparous 0.54 (0.20–1.45)   0.54 (0.20–1.45)  
BODY MASS INDEX
Underweight/Normal 1 0.529    1 0.529   
Overweight/obese 1.31 (0.55–3.10)    1.31 (0.55–3.10)   
PRE GESTATIONAL DIABETES
Yes 1.24 (0.22–6.74) 0.80    1.24 (0.22–6.74) 0.80   
No 1    1   
GESTATIONAL DIABETES
Yes 2.35 (0.93–5.92) 0.07    2.35 (0.93–5.92) 0.07   
No 1    1   
HYPERTENSION
No 1   1   1   1  
Pre-eclampsia/ Gestational Hypertension 2. 65(1.81–8.63) 0.002 2.48 (0.72–8.53) 0.03* 2. 65(1.81–8.63) 0.002 2.46(0.83–8.77) 0.05*
Chronic Hypertension 12.74 (2.34–36.91) 12.71 (2.37–67.99) 12.74 (2.34–36.91) 11.34 (2.63–64.34)  
  1. *Fischer test applied. P-value significant at <=0.05