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Table 5 Association of thyroid antibodies with neonatal outcomes in hypothyroid pregnancies

From: Association of thyroid antibodies status on the outcomes of pregnant women with hypothyroidism (maternal hypothyroidism on pregnancy outcomes, MHPO-4)

  Anti-TPO P value Odds ratio 95% CI Anti-TG P value Odds ratio 95% CI
Neonatal outcomes Positive
N (%)
N = 83
Negative
N (%)
N = 44
Positive
N (%)
N = 64
Negative
N (%)
N = 63
Low APGAR at 5 min
 Yes 1 (1.2%) 0 (0.0%) 1.000a 1.524 1.343- 0 (0.0%) 1 (1.6%)   2.049 1.712-
 No 82 (98.8%) 43 (100.0%)    1.731 64 (100.0%) 61 (98.4%) 0.492a   2.452
Premature Birth
 Yes 18 (21.7%) 13 (29.5%) 0.593 0.660 0.287–1.517 13 (20.3%) 18 (28.6%) 0.307 0.637 0.281-
 No 65 (78.3%) 31 (70.5%)     51 (79.7%) 45 (71.4%)    1.444
Low birth weight
 Yes 18 (22.0%) 10 (22.7%) 0.920 0.956 0.398–2.300 10 (15.6%) 18 (29.0%) 0.070 0.453 0.190-
 No 64 (78.0%) 34 (77.3%)     54 (84.4%) 44 (71.0%)    1.080
Neonatal Respiratory distress
 Yes 5 (6.0%) 3 (6.8%) 0.861 0.876 0.199- 1 (1.6%) 7 (11.1%) 0.033a 0.127 0.015-
 No 78 (94.0%) 41 (93.2%)    3.850 63 (98.4%) 56 (88.9%)    1.064
Sepsis
 Yes 2 (2.4%) 2 (4.5%) 0.609a 0.519 0.071- 1 (1.6%) 3 (4.8%) 0.302 0.317 0.032-
 No 81 (97.6%) 42 (95.5%)    3.813 63 (98.4%) 60 (95.2%)    3.137
Neonatal Jaundice
 Yes 32 (38.6%) 12 (27.3%) 0.204 1.673 0.754- 23 (35.9%) 21 (33.3%) 0.758 1.122 0.540-
 No 51 (61.4%) 32 (72.7%)    3.713 41 (64.1%) 42 (66.7%)    2.332
Hypocalcaemia
 Yes 4 (4.8%) 3 (6.8%) 0.693a 0.692 0.148- 2 (3.1%) 5 (7.9%) 0.235 0.374 0.070-
 No 79 (95.2%) 41 (93.2%)    3.240 62 (96.9%) 58 (92.1%)    2.005
NICU admission < 24 h
 Yes 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%)
 No 83 (100.0%) 44 (100.0%)     64 (100.0%) 63 (100.0%)    
NICU admission > 24 h
 Yes 10 (12.0%) 4 (9.1%) 0.613 1.370 0.404–4.649 3 (4.7%) 11 (17.5%) 0.022 0.232 0.062–0.878
 No 73 (88.0%) 40 (90.9%)     61 (95.3%) 52 (82.5%)    
Neonatal death
 Yes (Early & Late) 2 (2.4%) 0 (0.0%) 0.544a 1.543 1.356- 2 (3.1%) 0 (0.0%) 0.496a 2.016 1.690-
 No 81 (97.6%) 44 (100.0%)    1.756 62 (96.9%) 63 (100.0%)    2.406
Gestational age
 Preterm (28–36) 21 (25.3%) 13 (29.5%) 0.607 1.238b 0.548- 16 (25.0%) 18 (28.6%) 0.649 1.200 0.546-
 Term (37–42) 62 (74.7%) 31 (70.5%)    2.797 48 (75.0%) 45 (71.4%)    2.635
Birth weight
 Small for Gestational Age (SGA <2500) 19 (23.2%) 10 (22.7%) 0.955 1.025 0.429- 11 (17.2%) 18 (29.0%) 0.114 0.507 0.217-
 Appropriate for Gestational Age (AGA 2500–4000) 63 (76.8%) 34 (77.3%)    2.452 53 (82.8%) 44 (71.0%)    1.187
  1. P-values calculated by Chi square test applied. aFischer exact test applied. APGAR, Appearance, Pulse, Grimace, Activity, and Respiration. NICU, neonatal intensive care admission. bOdds ratio for Preterm