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Table 5 Association of thyroid antibodies with neonatal outcomes in hypothyroid pregnancies

From: Association of thyroid antibodies status on the outcomes of pregnant women with hypothyroidism (maternal hypothyroidism on pregnancy outcomes, MHPO-4)

 

Anti-TPO

P value

Odds ratio

95% CI

Anti-TG

P value

Odds ratio

95% CI

Neonatal outcomes

Positive

N (%)

N = 83

Negative

N (%)

N = 44

Positive

N (%)

N = 64

Negative

N (%)

N = 63

Low APGAR at 5 min

 Yes

1 (1.2%)

0 (0.0%)

1.000a

1.524

1.343-

0 (0.0%)

1 (1.6%)

 

2.049

1.712-

 No

82 (98.8%)

43 (100.0%)

  

1.731

64 (100.0%)

61 (98.4%)

0.492a

 

2.452

Premature Birth

 Yes

18 (21.7%)

13 (29.5%)

0.593

0.660

0.287–1.517

13 (20.3%)

18 (28.6%)

0.307

0.637

0.281-

 No

65 (78.3%)

31 (70.5%)

   

51 (79.7%)

45 (71.4%)

  

1.444

Low birth weight

 Yes

18 (22.0%)

10 (22.7%)

0.920

0.956

0.398–2.300

10 (15.6%)

18 (29.0%)

0.070

0.453

0.190-

 No

64 (78.0%)

34 (77.3%)

   

54 (84.4%)

44 (71.0%)

  

1.080

Neonatal Respiratory distress

 Yes

5 (6.0%)

3 (6.8%)

0.861

0.876

0.199-

1 (1.6%)

7 (11.1%)

0.033a

0.127

0.015-

 No

78 (94.0%)

41 (93.2%)

  

3.850

63 (98.4%)

56 (88.9%)

  

1.064

Sepsis

 Yes

2 (2.4%)

2 (4.5%)

0.609a

0.519

0.071-

1 (1.6%)

3 (4.8%)

0.302

0.317

0.032-

 No

81 (97.6%)

42 (95.5%)

  

3.813

63 (98.4%)

60 (95.2%)

  

3.137

Neonatal Jaundice

 Yes

32 (38.6%)

12 (27.3%)

0.204

1.673

0.754-

23 (35.9%)

21 (33.3%)

0.758

1.122

0.540-

 No

51 (61.4%)

32 (72.7%)

  

3.713

41 (64.1%)

42 (66.7%)

  

2.332

Hypocalcaemia

 Yes

4 (4.8%)

3 (6.8%)

0.693a

0.692

0.148-

2 (3.1%)

5 (7.9%)

0.235

0.374

0.070-

 No

79 (95.2%)

41 (93.2%)

  

3.240

62 (96.9%)

58 (92.1%)

  

2.005

NICU admission < 24 h

 Yes

0 (0.0%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

 No

83 (100.0%)

44 (100.0%)

   

64 (100.0%)

63 (100.0%)

   

NICU admission > 24 h

 Yes

10 (12.0%)

4 (9.1%)

0.613

1.370

0.404–4.649

3 (4.7%)

11 (17.5%)

0.022

0.232

0.062–0.878

 No

73 (88.0%)

40 (90.9%)

   

61 (95.3%)

52 (82.5%)

   

Neonatal death

 Yes (Early & Late)

2 (2.4%)

0 (0.0%)

0.544a

1.543

1.356-

2 (3.1%)

0 (0.0%)

0.496a

2.016

1.690-

 No

81 (97.6%)

44 (100.0%)

  

1.756

62 (96.9%)

63 (100.0%)

  

2.406

Gestational age

 Preterm (28–36)

21 (25.3%)

13 (29.5%)

0.607

1.238b

0.548-

16 (25.0%)

18 (28.6%)

0.649

1.200

0.546-

 Term (37–42)

62 (74.7%)

31 (70.5%)

  

2.797

48 (75.0%)

45 (71.4%)

  

2.635

Birth weight

 Small for Gestational Age (SGA <2500)

19 (23.2%)

10 (22.7%)

0.955

1.025

0.429-

11 (17.2%)

18 (29.0%)

0.114

0.507

0.217-

 Appropriate for Gestational Age (AGA 2500–4000)

63 (76.8%)

34 (77.3%)

  

2.452

53 (82.8%)

44 (71.0%)

  

1.187

  1. P-values calculated by Chi square test applied. aFischer exact test applied. APGAR, Appearance, Pulse, Grimace, Activity, and Respiration. NICU, neonatal intensive care admission. bOdds ratio for Preterm