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Table 2 Detective efficiency of common chromosomal aneuploidies by NIPS

From: Efficiency of non-invasive prenatal screening in pregnant women at advanced maternal age

Trisomy

Sensitivity

Specificity

PPV (95% CI)

NPV (95% CI)

Rate of TP

T21

99.11 (94.62–99.99)

99.96 (99.93–99.98)

90.98 (84.08–95.19)

100 (99.98–100)

0.382

T18

100 (88.53–100)

99.94 (99.91–99.97)

67.92 (53.55–79.70)

100 (99.98–100)

0.123

T13

100 (51.09–100)

99.96 (99.92–99.98)

27.78 (12.17–51.20)

100 (99.98–100)

0.017

  1. Data are presented as n (%), unless otherwise indicated. PPV, positive predictive value; NPV, negative predictive value; CI, confidence intervals